Association of gait and balance disorders with age-related white matter changes: the LADIS study.

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Fältnamn	Indikatorer	Metadata
000		05279naa a2200985 4500
001		oai:gup.ub.gu.se/87556
003		SwePub
008		240528s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:116772474
024	7	a https://gup.ub.gu.se/publication/875562 URI
024	7	a https://doi.org/10.1212/01.wnl.0000305959.46197.e62 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1167724742 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Baezner, H4 aut
245	1 0	a Association of gait and balance disorders with age-related white matter changes: the LADIS study.
264		c 2008-03-17
264	1	b Ovid Technologies (Wolters Kluwer Health),c 2008
520		a OBJECTIVE: In the Leukoaraiosis and Disability (LADIS) Study, 11 European centers are evaluating the role of age-related white matter changes (ARWMC) as an independent determinant of the transition to disability in the elderly (65 to 84 years). We aimed at determining the influence of ARWMC on different objective measures of gait and balance. METHODS: Six hundred thirty-nine nondisabled individuals were prospectively enrolled and are being followed-up for 3 years. Subjects are graded in three standardized categories of ARWMC (mild, moderate, and severe) according to central MRI reading. Quantitative tests of gait and balance include the Short Physical Performance Battery (SPPB; range: 0 [poor] to 12 [normal]), a timed 8-m walk, and a timed single leg stance test. RESULTS: In cross-sectional analysis, deficiencies in gait and balance performance were correlated with the severity of ARWMC (SPPB: 10.2 +/- 2.1 in the mild, 9.9 +/- 2.0 in the moderate, 8.9 +/- 2.6 in the severe group; p < 0.001). Walking speed correlated with the severity of ARWMC (1.24 +/- 0.28 m/second in the mild, 1.18 +/- 0.32 m/second in the moderate, and 1.09 +/- 0.31 m/second in the severe group; p < 0.001). Balance was best in individuals with mild ARWMC (single leg stance time: 18.9 +/- 10.8 seconds) compared with moderate and severe ARWMC (16.4 +/- 10.8 and 13.6 +/- 11.2 seconds) (p < 0.001). Physically inactive individuals had a higher risk of a pathologic SPPB score (moderate vs mild ARWMC: odds ratio 1.60, 95% CI 1.02 to 2.52; severe vs mild ARWMC: odds ratio 1.75, 95% CI 1.09 to 2.80). CONCLUSIONS: Our findings support a strong association between the severity of age-related white matter changes and the severity of gait and motor compromise. Physical activity might have the potential to reduce the risk of limitations in mobility.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a Age Factors
653		a Aged
653		a Aged
653		a 80 and over
653		a Aging
653		a pathology
653		a Brain
653		a pathology
653		a physiopathology
653		a Cohort Studies
653		a Comorbidity
653		a Cross-Sectional Studies
653		a Disease Progression
653		a Exercise Therapy
653		a standards
653		a Female
653		a Gait Disorders
653		a Neurologic
653		a epidemiology
653		a pathology
653		a physiopathology
653		a Humans
653		a Leukoaraiosis
653		a epidemiology
653		a pathology
653		a physiopathology
653		a Male
653		a Nerve Fibers
653		a Myelinated
653		a pathology
653		a Physical Fitness
653		a physiology
653		a Predictive Value of Tests
653		a Prevalence
653		a Prospective Studies
653		a Severity of Illness Index
653		a Vestibular Diseases
653		a epidemiology
653		a pathology
653		a physiopathology
700	1	a Blahak, C4 aut
700	1	a Poggesi, A4 aut
700	1	a Pantoni, L4 aut
700	1	a Inzitari, D4 aut
700	1	a Chabriat, H4 aut
700	1	a Erkinjuntti, T4 aut
700	1	a Fazekas, F4 aut
700	1	a Ferro, J M4 aut
700	1	a Langhorne, P4 aut
700	1	a O'Brien, J4 aut
700	1	a Scheltens, P4 aut
700	1	a Visser, M C4 aut
700	1	a Wahlund, L Ou Karolinska Institutet4 aut
700	1	a Waldemar, G4 aut
700	1	a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand
700	1	a Hennerici, M G4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Neurologyd : Ovid Technologies (Wolters Kluwer Health)g 70:12, s. 935-42q 70:12<935-42x 1526-632Xx 0028-3878
856	4 8	u https://gup.ub.gu.se/publication/87556
856	4 8	u https://doi.org/10.1212/01.wnl.0000305959.46197.e6
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:116772474

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By the author/editor: Baezner, H; Blahak, C; Poggesi, A; Pantoni, L; Inzitari, D; Chabriat, H; show more...; Erkinjuntti, T; Fazekas, F; Ferro, J M; Langhorne, P; O'Brien, J; Scheltens, P; Visser, M C; Wahlund, L O; Waldemar, G; Wallin, Anders, ...; Hennerici, M G; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Neurology

By the university: University of Gothenburg; Karolinska Institutet

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