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Sökning: WFRF:(Borrachero Conejo A. I.) > Biomimetic graphene...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006017naa a2200565 4500
001oai:research.chalmers.se:0b6bfa39-a9d9-4832-901a-d93f9c0f7848
003SwePub
008180906s2018 | |||||||||||000 ||eng|
0247 a https://doi.org/10.1039/c8tb01410h2 DOI
0247 a https://research.chalmers.se/publication/5048162 URI
040 a (SwePub)cth
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Durso, M.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
2451 0a Biomimetic graphene for enhanced interaction with the external membrane of astrocytes
264 c 2018
264 1b Royal Society of Chemistry (RSC),c 2018
338 a electronic2 rdacarrier
520 a Graphene and graphene substrates display huge potential as material interfaces for devices and biomedical tools targeting the modulation or recovery of brain functionality. However, to be considered reliable neural interfaces, graphene-derived substrates should properly interact with astrocytes, favoring their growth and avoiding adverse gliotic reactions. Indeed, astrocytes are the most abundant cells in the human brain and they have a crucial physiological role to maintain its homeostasis and modulate synaptic transmission. In this work, we describe a new strategy based on the chemical modification of graphene oxide (GO) with a synthetic phospholipid (PL) to improve interaction of GO with brain astroglial cells. The PL moieties were grafted on GO sheets through polymeric brushes obtained by atom-transfer radical-polymerization (ATRP) between acryloyl-modified PL and GO nanosheets modified with a bromide initiator. The adhesion of primary rat cortical astrocytes on GO-PL substrates increased by about three times with respect to that on glass substrates coated with standard adhesion agents (i.e. poly-d-lysine, PDL) as well as with respect to that on non-functionalized GO. Moreover, we show that astrocytes seeded on GO-PL did not display significant gliotic reactivity, indicating that the material interface did not cause a detrimental inflammatory reaction when interacting with astroglial cells. Our results indicate that the reported biomimetic approach could be applied to neural prosthesis to improve cell colonization and avoid glial scar formation in brain implants. Additionally, improved adhesion could be extremely relevant in devices targeting neural cell sensing/modulation of physiological activity.
650 7a TEKNIK OCH TEKNOLOGIERx Materialteknik0 (SwePub)2052 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Materials Engineering0 (SwePub)2052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng
7001 a Borrachero-Conejo, A. I.u Istituto per lo Studio dei Materiali Nanostrutturati del C.N.R.4 aut
7001 a Bettini, C.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
7001 a Treossi, E.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
7001 a Scidà, A.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
7001 a Saracino, E.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
7001 a Gazzano, M.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
7001 a Christian, Meganneu Consiglo Nazionale Delle Richerche4 aut
7001 a Morandi, V.u Consiglo Nazionale Delle Richerche4 aut
7001 a Tuci, G.u Consiglo Nazionale Delle Richerche4 aut
7001 a Giambastiani, G.u Kazan Federal University,Consiglo Nazionale Delle Richerche4 aut
7001 a Ottaviano, L.u Universita degli Studi dell'Aquila,University of L'Aquila4 aut
7001 a Perrozzi, F.4 aut
7001 a Benfenati, V.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
7001 a Melucci, M.u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR)4 aut
7001 a Palermo, Vincenzo,d 1972u Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR),Institute for organic syntheses and photoreactivity (ISOF-CNR),Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)palermo
7102 a Istituto per la Sintesi Organica e la Fotoreattività (ISOF-CNR)b Istituto per lo Studio dei Materiali Nanostrutturati del C.N.R.4 org
7730 t Journal of Materials Chemistry Bd : Royal Society of Chemistry (RSC)g 6:33, s. 5335-5342q 6:33<5335-5342x 2050-7518x 2050-750X
8564 u https://research.chalmers.se/publication/504816/file/504816_Fulltext.pdfx primaryx freey FULLTEXT
8564 u https://pubs.rsc.org/en/content/articlepdf/2018/tb/c8tb01410h
8564 8u https://doi.org/10.1039/c8tb01410h
8564 8u https://research.chalmers.se/publication/504816

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