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Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

Luis, Tiago C. (author)
University of Oxford
Luc, Sidinh (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Boston Children's Hospital,University of Oxford,Harvard University
Mizukami, Takuo (author)
University of Oxford
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Boukarabila, Hanane (author)
University of Oxford
Thongjuea, Supat (author)
University of Oxford
Woll, Petter S. (author)
University of Oxford
Azzoni, Emanuele (author)
University of Oxford
Giustacchini, Alice (author)
University of Oxford
Lutteropp, Michael (author)
University of Oxford
Bouriez-Jones, Tiphaine (author)
University of Oxford
Vaidya, Harsh (author)
University of Edinburgh
Mead, Adam J. (author)
University of Oxford
Atkinson, Deborah (author)
University of Oxford
Böiers, Charlotta (author)
Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Utvecklingslymfopoes och leukemi,Forskargrupper vid Lunds universitet,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Developmental lymphopoiesis and leukemia,Lund University Research Groups
Carrelha, Joana (author)
University of Oxford
MacAulay, Iain C. (author)
University of Oxford
Patient, Roger (author)
University of Oxford
Geissmann, Frederic (author)
King's College London,Memorial Sloan-Kettering Cancer Center
Nerlov, Claus (author)
University of Oxford
Sandberg, Rickard (author)
Karolinska Institutet,Karolinska Institute
De Bruijn, Marella F T R (author)
University of Oxford
Blackburn, C. Clare (author)
University of Edinburgh
Godin, Isabelle (author)
Institut Gustave Roussy,University of Paris-Saclay,National Institute for Health and Medical Research, France
Jacobsen, Sten Eirik W (author)
Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,University of Oxford
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 (creator_code:org_t)
2016-10-03
2016
English 12 s.
In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 17:12, s. 1424-1435
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  • Journal article (peer-reviewed)
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  • The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functional and molecular properties of embryonic thymopoiesis-initiating progenitors (T-IPs) before their entry into the thymus and activation of Notch signaling. T-IPs did not include multipotent stem cells or molecular evidence of T cell-restricted progenitors. Instead, single-cell molecular and functional analysis demonstrated that most fetal T-IPs expressed genes of and had the potential to develop into lymphoid as well as myeloid components of the immune system. Moreover, studies of embryos deficient in the transcriptional regulator RBPJ demonstrated that canonical Notch signaling was not involved in pre-thymic restriction to the T cell lineage or the migration of T-IPs.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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