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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004374naa a2200985 4500
001oai:DiVA.org:uu-15051
003SwePub
008080204s2007 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150512 URI
024a https://doi.org/10.1038/ng20532 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Peacock, Christopher S4 aut
2451 0a Comparative genomic analysis of three Leishmania species that cause diverse human disease.
264 c 2007-06-17
264 1b Springer Science and Business Media LLC,c 2007
338 a print2 rdacarrier
520 a Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a Amino Acid Sequence
653 a Animals
653 a Genome
653 a Genomics
653 a Humans
653 a Leishmania/*genetics
653 a Leishmania braziliensis/genetics
653 a Leishmania infantum/genetics
653 a Leishmania major/genetics
653 a Leishmaniasis/*parasitology
653 a Leishmaniasis; Cutaneous/parasitology
653 a Leishmaniasis; Visceral/parasitology
653 a Molecular Sequence Data
653 a Biology
653 a Biologi
700a Seeger, Kathy4 aut
700a Harris, David4 aut
700a Murphy, Lee4 aut
700a Ruiz, Jeronimo C4 aut
700a Quail, Michael A4 aut
700a Peters, Nick4 aut
700a Adlem, Ellen4 aut
700a Tivey, Adrian4 aut
700a Aslett, Martin4 aut
700a Kerhornou, Arnaud4 aut
700a Ivens, Alasdair4 aut
700a Fraser, Audrey4 aut
700a Rajandream, Marie-Adele4 aut
700a Carver, Tim4 aut
700a Norbertczak, Halina4 aut
700a Chillingworth, Tracey4 aut
700a Hance, Zahra4 aut
700a Jagels, Kay4 aut
700a Moule, Sharon4 aut
700a Ormond, Doug4 aut
700a Rutter, Simon4 aut
700a Squares, Rob4 aut
700a Whitehead, Sally4 aut
700a Rabbinowitsch, Ester4 aut
700a Arrowsmith, Claire4 aut
700a White, Brian4 aut
700a Thurston, Scott4 aut
700a Bringaud, Frédéric4 aut
700a Baldauf, Sandra Lu Uppsala universitet,Systematisk botanik4 aut0 (Swepub:uu)sanba878
700a Faulconbridge, Adam4 aut
700a Jeffares, Daniel4 aut
700a Depledge, Daniel P4 aut
700a Oyola, Samuel O4 aut
700a Hilley, James D4 aut
700a Brito, Loislene O4 aut
700a Tosi, Luiz R O4 aut
700a Barrell, Barclay4 aut
700a Cruz, Angela K4 aut
700a Mottram, Jeremy C4 aut
700a Smith, Deborah F4 aut
700a Berriman, Matthew4 aut
710a Uppsala universitetb Systematisk botanik4 org
773t Nature Geneticsd : Springer Science and Business Media LLCg 39:7, s. 839-847q 39:7<839-847x 1061-4036x 1546-1718
856u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17572675&dopt=Citation
856u https://europepmc.org/articles/pmc2592530?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15051
8564 8u https://doi.org/10.1038/ng2053

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