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Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China

Ning, Yujie (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Minhan, Hu (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Yi, Gong (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
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Ruitian, Huang (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Ke, Xu (författare)
Department of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No.555, Xi’an, People’s Republic of China
Sijie, Chen (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Feiyu, Zhang (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Yanli, Liu (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Feihong, Chen (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Yanhai, Chang (författare)
Shaanxi Provincial People’s Hospital, Xi’an, People’s Republic of China
Guanghui, Zhao (författare)
Department of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No.555, Xi’an, People’s Republic of China
Cheng, Li (författare)
Shaanxi Institute of Endemic Disease Prevention and Control, Xi’an, People’s Republic of China
Rong, Zhou (författare)
Shaanxi Institute of Endemic Disease Prevention and Control, Xi’an, People’s Republic of China
Lammi, Mikko, 1961- (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China,Chondrogeni and osteogenic differentiation
Xiong, Guo (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China
Xi, Wang (författare)
School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China; Department of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China; Global Health Institute, Xi’an Jiaotong University Health Science Center, Xi’an, People’s Republic of China
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School of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, People’s Republic of China Department of Joint Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No555, Xi’an, People’s Republic of China (creator_code:org_t)
2022-05-30
2022
Engelska.
Ingår i: Arthritis Research & Therapy. - : BioMed Central. - 1478-6362. ; 24:1
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.Methods: Fecal samples collected from OA and KBD patients were used to characterize the gut microbiota using 16S rDNA gene sequencing. To identify whether gut microbial changes at the species level are associated with the genes or functions of the gut bacteria between OA and KBD groups, metagenomic sequencing of fecal samples from OA and KBD subjects was performed.Results: The OA group was characterized by elevated Epsilonbacteraeota and Firmicutes levels. A total of 52 genera were identified to be significantly differentially abundant between the two groups. The genera Raoultella, Citrobacter, Flavonifractor, g__Lachnospiraceae_UCG-004, and Burkholderia-Caballeronia-Paraburkholderia were more abundant in the OA group. The KBD group was characterized by higher Prevotella_9, Lactobacillus, Coprococcus_2, Senegalimassilia, and Holdemanella. The metagenomic sequencing showed that the Subdoligranulum_sp._APC924/74, Streptococcus_parasanguinis, and Streptococcus_salivarius were significantly increased in abundance in the OA group compared to those in the KBD group, and the species Prevotella_copri, Prevotella_sp._CAG:386, and Prevotella_stercorea were significantly decreased in abundance in the OA group compared to those in the KBD group by using metagenomic sequencing.Conclusion: Our study provides a comprehensive landscape of the gut microbiota between OA and KBD patients and provides clues for better understanding the mechanisms underlying the pathogenesis of OA and KBD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)

Nyckelord

Osteoarthritis
Kashin-Beck disease
16S sequencing
Metagenomic sequencing
Microbiota
mikrobiologi
Microbiology
molecular biotechnology (dept of cell- and molecular biology)
molekylär bioteknik (inst f cell- o molekylärbiologi)
reumatologi
rheumatology

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