Search: WFRF:(Christiansen Evald Hoj) > (2020) > Randomised comparis...
Fältnamn | Indikatorer | Metadata |
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000 | 07130naa a2200685 4500 | |
001 | oai:DiVA.org:oru-81576 | |
003 | SwePub | |
008 | 200506s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-815762 URI |
024 | 7 | a https://doi.org/10.1136/openhrt-2018-0009472 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kumsars, Indulisu Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia4 aut |
245 | 1 0 | a Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch :b the Nordic-Baltic Bifurcation Study IV |
264 | c 2020-01-19 | |
264 | 1 | b BMJ Publishing Group Ltd,c 2020 |
338 | a print2 rdacarrier | |
500 | a Funding Agency:Cordis Corp | |
520 | a Background: It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation.Methods: The study was a randomised, superiority trial. Enrolment required a SB >= 2.75 mm, >= 50% diameter stenosis in both vessels, and allowed SB lesion length up to 15 mm. The primary endpoint was a composite of cardiac death, non-procedural myocardial infarction and target lesion revascularisation at 6 months. Two-year clinical follow-up was included in this primary reporting due to lower than expected event rates.Results: A total of 450 patients were assigned to simple stenting (n = 221) or complex stenting (n=229) in 14 Nordic and Baltic centres. Two-year follow-up was available in 218 (98.6%) and 228 (99.5%) patients, respectively. The primary endpoint of major adverse cardiac events (MACE) at 6 months was 5.5% vs 2.2% (risk differences 3.2%, 95% CI -0.2 to 6.8, p=0.07) and at 2 years 12.9% vs 8.4% (HR 0.63, 95% CI 0.35 to 1.13, p = 0.12) after simple versus complex treatment. In the subgroup treated by newer generation drug-eluting stents, MACE was 12.0% vs 5.6% (HR 0.45, 95% CI 0.17 to 1.17, p = 0.10) after simple versus complex treatment.Conclusion: In the treatment of bifurcation lesions involving a large SB with ostial stenosis, routine two-stent techniques did not improve outcome significantly compared with treatment by the simpler main vessel stenting technique after 2 years. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Holm, Niels Ramsingu Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark4 aut |
700 | 1 | a Niemelä, Mattiu Department of Cardiology, Oulu University Hospital, Oulu, Finland4 aut |
700 | 1 | a Erglis, Andrejsu Research Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia4 aut |
700 | 1 | a Kervinen, Kariu Department of Cardiology, Oulu University Hospital, Oulu, Finland4 aut |
700 | 1 | a Christiansen, Evald Hoju Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark4 aut |
700 | 1 | a Maeng, Michaelu Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark4 aut |
700 | 1 | a Dombrovskis, Andisu Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia4 aut |
700 | 1 | a Abraitis, Vytautasu Department of Cardiology, Vilnius University Hospital, Vilnius, Lithuania4 aut |
700 | 1 | a Kibarskis, Aleksandrasu Department of Cardiology, Vilnius University Hospital, Vilnius, Lithuania4 aut |
700 | 1 | a Trovik, Thoru Department of Cardiology, University of North Norway, Tromsoe, Norway4 aut |
700 | 1 | a Latkovskis, Gustavsu Research Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia4 aut |
700 | 1 | a Sondore, Daceu Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia4 aut |
700 | 1 | a Narbute, Ingau Research Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia4 aut |
700 | 1 | a Terkelsen, Christian Juhlu Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark4 aut |
700 | 1 | a Eskola, Markkuu Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland4 aut |
700 | 1 | a Romppanen, Hannuu Department of cardiology, Heart Center, Kuopio University Hospital, Kuopio, Finland4 aut |
700 | 1 | a Laine, Mikau Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland4 aut |
700 | 1 | a Jensen, Lisette Okkelsu Department of Cardiology, Odense University Hospital, Odense, Denmark4 aut |
700 | 1 | a Pietila, Mikkou Department of Cardiology, Turku University Hospital, Turku, Finland4 aut |
700 | 1 | a Gunnes, Palu Heart Center, Sørlandet Hospital, Arendal, Norway4 aut |
700 | 1 | a Hebsgaard, Lasseu Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark4 aut |
700 | 1 | a Fröbert, Ole,d 1964-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology4 aut0 (Swepub:oru)oft |
700 | 1 | a Calais, Fredrik,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology4 aut0 (Swepub:oru)fcs |
700 | 1 | a Hartikainen, Juhau Department of cardiology, Heart Center, Kuopio University Hospital, Kuopio, Finland4 aut |
700 | 1 | a Aarøe, Jensu Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark4 aut |
700 | 1 | a Ravkilde, Janu Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark4 aut |
700 | 1 | a Engstrøm, Thomasu Department of Cardiology, Rigshospitalet, Copenhagen, Denmark4 aut |
700 | 1 | a Steigen, Terje K.u Department of Cardiology, University Hospital of North Norway, Tromsoe and Cardiovascular Diseases Research Group, UiT The Arctic University of Norway, Tromsø, Norway4 aut |
700 | 1 | a Thuesen, Leifu Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark4 aut |
700 | 1 | a Lassen, Jens F.u Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark4 aut |
710 | 2 | a Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latviab Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark4 org |
773 | 0 | t Open heartd : BMJ Publishing Group Ltdg 7:1q 7:1x 2053-3624 |
856 | 4 | u https://doi.org/10.1136/openhrt-2018-000947y Fulltext |
856 | 4 | u https://openheart.bmj.com/content/openhrt/7/1/e000947.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81576 |
856 | 4 8 | u https://doi.org/10.1136/openhrt-2018-000947 |
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