Search: WFRF:(Cima Michael J.) >
A gastric resident ...
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
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- Verma, Malvika (author)
- MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Vishwanath, Karan (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Eweje, Feyisope (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA.
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- Roxhed, Niclas (author)
- KTH,Mikro- och nanosystemteknik
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- Grant, Tyler (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Castaneda, Macy (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Steiger, Christoph (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Mazdiyasni, Hormoz (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Bensel, Taylor (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Minahan, Daniel (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Soares, Vance (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Salama, John A. F. (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Lopes, Aaron (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Hess, Kaitlyn (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Cleveland, Cody (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Fulop, Daniel J. (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Univ Delaware, Biomed Engn Dept, 161 Colburn Lab, Newark, DE 19716 USA.
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- Hayward, Alison (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Div Comparat Med, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Collins, Joy (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Tamang, Siddartha M. (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Hua, Tiffany (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Ikeanyi, Chinonyelum (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Zeidman, Gal (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Mule, Elizabeth (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Boominathan, Sooraj (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Popova, Ellena (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Miller, Jonathan B. (author)
- MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Sloan Sch Management, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Bellinger, Andrew M. (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Dept Med, Cardiovasc Div, Boston, MA 02115 USA.;Lyndra Therapeut Inc, Watertown, MA 02472 USA.
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- Collins, David (author)
- Management Sci Hlth, Medford, MA 02155 USA.;Boston Univ, Sch Publ Hlth, Boston, MA 02118 USA.
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- Leibowitz, Dalia (author)
- MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Batra, Shelly (author)
- Operat ASHA, New Delhi 110076, India.
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- Ahuja, Sandeep (author)
- Operat ASHA, New Delhi 110076, India.
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- Bajiya, Manju (author)
- Operat ASHA, New Delhi 110076, India.
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- Batra, Sonali (author)
- Operat ASHA, New Delhi 110076, India.
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- Sarin, Rohit (author)
- Natl Inst TB & Resp Dis, New Delhi 110030, India.
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- Agarwal, Upasna (author)
- Natl Inst TB & Resp Dis, New Delhi 110030, India.
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- Khaparde, Sunil D. (author)
- Former Deputy Director Gen & Head Cent TB Div, New Delhi 110011, India.
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- Gupta, Neeraj K. (author)
- Safdarjang Hosp, Dept Resp Med, New Delhi 110029, India.
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- Gupta, Deepak (author)
- All India Inst Med Sci, Div Pulm & Crit Care Med, New Delhi 110029, India.
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- Bhatnagar, Anuj K. (author)
- Rajan Babu Inst Pulm Med & TB, New Delhi 110009, India.
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- Chopra, Kamal K. (author)
- New Delhi TB Ctr, New Delhi 110002, India.
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- Sharma, Nandini (author)
- Maulana Azad Med Coll, Dept Community Med, New Delhi, India.
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- Khanna, Ashwani (author)
- Lok Nayak Hosp Chest Clin, New Delhi 110002, India.
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- Chowdhury, Jayeeta (author)
- Tata Trusts, Mumbai 400001, Maharashtra, India.
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- Stoner, Robert (author)
- MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Energy Initiat, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Slocum, Alexander H. (author)
- MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Cima, Michael J. (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Furin, Jennifer (author)
- Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA 02115 USA.
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- Langer, Robert (author)
- MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Media Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Traverso, Giovanni (author)
- MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA.;MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA;MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA. MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA. (creator_code:org_t)
- AMER ASSOC ADVANCEMENT SCIENCE, 2019
- 2019
- English.
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In: Science Translational Medicine. - : AMER ASSOC ADVANCEMENT SCIENCE. - 1946-6234 .- 1946-6242. ; 11:483
- Related links:
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https://stm.sciencem...
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Abstract
Subject headings
Close
- Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Verma, Malvika
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Vishwanath, Kara ...
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Eweje, Feyisope
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Roxhed, Niclas
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Grant, Tyler
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Castaneda, Macy
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show more...
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Steiger, Christo ...
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Mazdiyasni, Horm ...
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Bensel, Taylor
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Minahan, Daniel
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Soares, Vance
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Salama, John A. ...
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Lopes, Aaron
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Hess, Kaitlyn
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Cleveland, Cody
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Fulop, Daniel J.
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Hayward, Alison
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Collins, Joy
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Tamang, Siddarth ...
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Hua, Tiffany
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Ikeanyi, Chinony ...
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Zeidman, Gal
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Mule, Elizabeth
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Boominathan, Soo ...
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Popova, Ellena
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Miller, Jonathan ...
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Bellinger, Andre ...
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Collins, David
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Leibowitz, Dalia
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Batra, Shelly
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Ahuja, Sandeep
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Bajiya, Manju
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Batra, Sonali
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Sarin, Rohit
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Agarwal, Upasna
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Khaparde, Sunil ...
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Gupta, Neeraj K.
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Gupta, Deepak
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Bhatnagar, Anuj ...
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Chopra, Kamal K.
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Sharma, Nandini
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Khanna, Ashwani
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Chowdhury, Jayee ...
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Stoner, Robert
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Slocum, Alexande ...
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Cima, Michael J.
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Furin, Jennifer
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Langer, Robert
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Traverso, Giovan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Science Translat ...
- By the university
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Royal Institute of Technology
