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Sökning: WFRF:(Claesson Welsh L) > (2005-2009) > Platelet-derived gr...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03481naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-12799 | |
| 003 | SwePub | |
| 008 | 080115s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-127992 URI |
| 024 | 7 | a https://doi.org/10.1161/01.ATV.0000282198.60701.942 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Magnusson, Peetra U.u Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)petrmagn |
| 245 | 1 0 | a Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro |
| 264 | 1 | c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a OBJECTIVE - Knockout studies have demonstrated crucial roles for the platelet-derived growth factor-B and its cognate receptor, platelet-derived growth factor receptor-β (PDGFR-β), in blood vessel maturation, that is, the coverage of newly formed vessels with mural cells/pericytes. This study describes the consequences of a constitutively activating mutation of the PDGFR-β (Pdgfrb) introduced into embryonic stem cells with respect to vasculogenesis/angiogenesis in vitro and in vivo. METHODS AND RESULTS - Embryonic stem cells were induced to either form teratomas in vivo or embryoid bodies, an in vitro model for mouse embryogenesis. Western blotting studies on embryoid bodies showed that expression of a single allele of the mutant Pdgfrb led to increased levels of PDGFR-β tyrosine phosphorylation and augmented downstream signal transduction. This was accompanied by enhanced vascular development, followed by exaggerated angiogenic sprouting with abundant pericyte coating as shown by immunohistochemistry/immunofluorescence. Pdgfrb embryoid bodies were characterized by increased expression of vascular endothelial growth factor (VEGF)-A and VEGF receptor-2; neutralizing antibodies against VEGF-A/VEGF receptor-2 blocked vasculogenesis and angiogenesis in mutant embryoid bodies. Moreover, Pdgfrb embryonic stem cell-derived teratomas in nude mice were more densely vascularized than wild-type teratomas. CONCLUSION - Increased PDGFR-β kinase activity is associated with elevated expression of VEGF-A and VEGF receptor-2, acting directly on endothelial cells and resulting in increased vessel formation. | |
| 653 | a Angiogenesis | |
| 653 | a Embryonic stem cells | |
| 653 | a Endothelial cells | |
| 653 | a PDGF | |
| 653 | a PDGF receptor | |
| 653 | a Signal transduction | |
| 653 | a Vasculogenesis | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Looman, Camillau Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut |
| 700 | 1 | a Åhgren, Aiveu Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)aiveahgr |
| 700 | 1 | a Wu, Yan4 aut |
| 700 | 1 | a Claesson-Welsh, Lenau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)lcl04207 |
| 700 | 1 | a Heuchel, Rainer L.u Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för genetik och patologi4 org |
| 773 | 0 | t Arteriosclerosis, Thrombosis and Vascular Biologyg 27:10, s. 2142-2149q 27:10<2142-2149x 1079-5642x 1524-4636 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-12799 |
| 856 | 4 8 | u https://doi.org/10.1161/01.ATV.0000282198.60701.94 |
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