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Sökning: WFRF:(Comans Emile F I) > (2011) > Absolute Quantifica...

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FältnamnIndikatorerMetadata
00003984naa a2200445 4500
001oai:DiVA.org:uu-189076
003SwePub
008121223s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1890762 URI
0247 a https://doi.org/10.1158/1078-0432.CCR-10-29332 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a van der Veldt, Astrid A M4 aut
2451 0a Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography
264 1c 2011
338 a print2 rdacarrier
520 a Purpose:Tumor resistance to docetaxel may be associated with reduced drug concentrations in tumor tissue. Positron emission tomography (PET) allows for quantification of radiolabeled docetaxel ([11C]docetaxel) kinetics and might be useful for predicting response to therapy. The primary objective was to evaluate the feasibility of quantitative [11C]docetaxel PET scans in lung cancer patients. The secondary objective was to investigate whether [11C]docetaxel kinetics were associated with tumor perfusion, tumor size, and dexamethasone administration.Experimental Design:Thirty-four lung cancer patients underwent dynamic PET–computed tomography (CT) scans using [11C]docetaxel. Blood flow was measured using oxygen-15 labeled water. The first 24 patients were premedicated with dexamethasone. For quantification of [11C]docetaxel kinetics, the optimal tracer kinetic model was developed and a noninvasive procedure was validated.Results:Reproducible quantification of [11C]docetaxel kinetics in tumors was possible using a noninvasive approach (image derived input function). Thirty-two lesions (size ≥4 cm3) were identified, having a variable net influx rate of [11C]docetaxel (range, 0.0023–0.0229 mL·cm−3·min−1). [11C]docetaxel uptake was highly related to tumor perfusion (Spearman's ρ = 0.815;P < 0.001), but not to tumor size (Spearman's ρ = −0.140; P = 0.446). Patients pretreated with dexamethasone showed lower [11C]docetaxel uptake in tumors (P = 0.013). Finally, in a subgroup of patients who subsequently received docetaxel therapy, relative high [11C]docetaxel uptake was related with improved tumor response.Conclusions:Quantification of [11C]docetaxel kinetics in lung cancer was feasible in a clinical setting. Variable [11C]docetaxel kinetics in tumors may reflect differential sensitivity to docetaxel therapy. Our findings warrant further studies investigating the predictive value of [11C]docetaxel uptake and the effects of comedication on [11C]docetaxel kinetics in tumors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
7001 a Lubberink, Marku Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands4 aut0 (Swepub:uu)marklubb
7001 a Greuter, Henri N4 aut
7001 a Comans, Emile F I4 aut
7001 a Herder, Gerarda J M4 aut
7001 a Yaqub, Maqsood4 aut
7001 a Schuit, Robert C4 aut
7001 a van Lingen, Arthur4 aut
7001 a Rizvi, S Nafees4 aut
7001 a Mooijer, Martien P J4 aut
7001 a Rijnders, Anneloes Y4 aut
7001 a Windhorst, Albert D4 aut
7001 a Smit, Egbert F4 aut
7001 a Hendrikse, N Harry4 aut
7001 a Lammertsma, Adriaan A4 aut
7102 a Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands4 org
7730 t Clinical Cancer Researchg 17:14, s. 4814-4824q 17:14<4814-4824x 1078-0432x 1557-3265
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-189076
8564 8u https://doi.org/10.1158/1078-0432.CCR-10-2933

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