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FältnamnIndikatorerMetadata
00006114naa a2200925 4500
001oai:gup.ub.gu.se/340739
003SwePub
008240910s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:239142134
009oai:prod.swepub.kib.ki.se:159327809
0247 a https://gup.ub.gu.se/publication/3407392 URI
0247 a https://doi.org/10.1016/j.envint.2024.1089312 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2391421342 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1593278092 URI
040 a (SwePub)gud (SwePub)kid (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Desalegn, Anteneh4 aut
2451 0a Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study
264 1c 2024
520 a Background: Phthalates are ubiquitous in the environment. Despite short half-lives, chronic exposure can lead to endocrine disruption. The safety of phthalate substitute DINCH is unclear. Objective: To evaluate associations between urinary concentrations of phthalate/DINCH metabolites and body mass index (BMI) z-score among children and adolescents. Method: We used Human Biomonitoring for Europe Aligned Studies data from 2876 children (12 studies, 6-12 years, 2014-2021) and 2499 adolescents (10 studies, 12-18 years, 2014-2021) with up to 14 phthalate/DINCH urinary metabolites. We used multilevel linear regression to assess associations between phthalate/DINCH concentrations and BMI z-scores, testing effect modification by sex. In a subset, Bayesian kernel machine regression (BKMR) and quantile-based g-computation assessed important predictors and mixture effects. Results: In children, we found few associations in single pollutant models and no interactions by sex (p p-interaction > 0.1). BKMR detected no relevant exposures (posterior inclusion probabilities, PIPs < 0.25), nor joint mixture effect. In adolescent single pollutant analysis, mono-ethyl phthalate (MEP) concentrations were associated with higher BMI z-score in males ((3 = 0.08, 95% CI: 0.001,0.15, per interquartile range increase in ln-transformed concentrations, p-interaction = 0.06). Conversely, mono-isobutyl phthalate (MiBP) was associated with a lower BMI z-score in both sexes ((3 =-0.13, 95 % CI:-0.19,-0.07, p-interaction = 0.74), as was sum of di(2-ethylhexyl) phthalate (& sum;DEHP) metabolites in females only ((3 =-0.08,95 % CI:-0.14,-0.02,p-interaction p-interaction = 0.01). In BKMR, higher BMI z-scores were predicted by MEP (PIP=0.90) and MBzP (PIP=0.84) in males. Lower BMI z-scores were predicted by MiBP (PIP=0.999), OH-MIDP (PIP=0.88) and OH-MINCH (PIP=0.72) in both sexes, less robustly by DEHP (PIP=0.61) in females. In quantile g-computation, the overall mixture effect was null for males, and trended negative for females ((3 =-0.11, 95 % CI:-0.25, 0.03, per joint exposure quantile). Conclusion: In this large Europe-wide study, we found age/sex-specific differences between phthalate metabolites and BMI z-score, stronger in adolescents. Longitudinal studies with repeated phthalate measurements are needed.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
7001 a Schillemans, Tessa4 aut
7001 a Papadopoulou, Eleni4 aut
7001 a Sakhi, Amrit K.4 aut
7001 a Haug, Line S.4 aut
7001 a Caspersen, Ida Henriette4 aut
7001 a Rodriguez-Carrillo, Andrea4 aut
7001 a Remy, Sylvie4 aut
7001 a Schoeters, Greet4 aut
7001 a Covaci, Adrian4 aut
7001 a Laeremans, Michelle4 aut
7001 a Fernandez, Mariana F.4 aut
7001 a Pedraza-Diaz, Susana4 aut
7001 a Jensen, Tina Kold4 aut
7001 a Frederiksen, Hanne4 aut
7001 a Akesson, Agnetau Karolinska Institutet4 aut
7001 a Cox, Bianca4 aut
7001 a D'Cruz, Shereen Cynthia4 aut
7001 a Rambaud, Loic4 aut
7001 a Riou, Margaux4 aut
7001 a Kolossa-Gehring, Marike4 aut
7001 a Gerofke, Antje4 aut
7001 a Murawski, Aline4 aut
7001 a Vogel, Nina4 aut
7001 a Gabriel, Catherine4 aut
7001 a Karakitsios, Spyros4 aut
7001 a Papaioannou, Nafsika4 aut
7001 a Sarigiannis, Dimosthenis4 aut
7001 a Barbone, Fabio4 aut
7001 a Rosolen, Valentina4 aut
7001 a Lignell, Sanna4 aut
7001 a Lindroos, Anna-Karin,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xlannw
7001 a Tratnik, Janja Snoj4 aut
7001 a Stajnko, Anja4 aut
7001 a Kosjek, Tina4 aut
7001 a Tkalec, Ziga4 aut
7001 a Fabelova, Lucia4 aut
7001 a Murinova, Lubica Palkovicova4 aut
7001 a Kolena, Branislav4 aut
7001 a Wimmerova, Sona4 aut
7001 a Szigeti, Tamas4 aut
7001 a Kozepesy, Szilvia4 aut
7001 a van den Brand, Annick4 aut
7001 a Zock, Jan-Paul4 aut
7001 a Janasik, Beata4 aut
7001 a Wasowicz, Wojciech4 aut
7001 a De Decker, Annelies4 aut
7001 a De Henauw, Stefaan4 aut
7001 a Govarts, Eva4 aut
7001 a Iszatt, Nina4 aut
7102 a Karolinska Institutetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org
7730 t ENVIRONMENT INTERNATIONALg 190q 190x 0160-4120x 1873-6750
8564 8u https://gup.ub.gu.se/publication/340739
8564 8u https://doi.org/10.1016/j.envint.2024.108931
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:239142134
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:159327809

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