SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Cuttano Roberto)
 

Sökning: WFRF:(Cuttano Roberto) > (2015) > Sulindac metabolite...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004091naa a2200505 4500
001oai:DiVA.org:uu-259652
003SwePub
008150810s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2596522 URI
0247 a https://doi.org/10.1073/pnas.15013521122 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bravi, Luca4 aut
2451 0a Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice
264 c 2015-06-24
264 1b Proceedings of the National Academy of Sciences,c 2015
338 a print2 rdacarrier
500 a This study was supported by grants (to E.D.) from TELETHON-GGP14149, Associazione Italiana per la Ricerca sul Cancro (AIRC) (AIRC IG 14471), "Special Program Molecular Clinical Oncology 5x1000" to AIRC-Gruppo Italiano Malattie Mieloproliferative, Fondazione Cassa di Risparmio delle Provincie Lombarde (CARIPLO) Contract 2012-0678, the European Community (Wnt for Brain Contract 268870; Innovative Training Networks Vessel 317250, Endostem-Health-2009-241440), and Fondazione CARIPLO Contract 2014-1038 (to N.R.). R.C. was supported by the FIRC fellowship 16617. Part of this work was funded by the European consortium European Research Area Network NEURON (to E.T.-L.).Dejana E and Lampugnani MG share the last authorship and corresponding.
520 a Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vascular malformations and very severe neurological consequences. At present, the only recommended treatment of CCM is surgical. Because surgery is often not applicable, pharmacological treatment would be highly desirable. We describe here a murine model of the disease that develops after endothelial-cell-selective ablation of the CCM3 gene. We report an early, cell-autonomous, Wnt-receptor-independent stimulation of beta-catenin transcription activity in CCM3-deficient endothelial cells both in vitro and in vivo and a triggering of a beta-catenin-driven transcription program that leads to endothelial-tomesenchymal transition. TGF-beta/BMP signaling is then required for the progression of the disease. We also found that the anti-inflammatory drugs sulindac sulfide and sulindac sulfone, which attenuate beta-catenin transcription activity, reduce vascular malformations in endothelial CCM3-deficient mice. This study opens previously unidentified perspectives for an effective pharmacological therapy of intracranial vascular cavernomas.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Övrig annan medicin och hälsovetenskap0 (SwePub)305992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Other Medical and Health Sciences not elsewhere specified0 (SwePub)305992 hsv//eng
653 a cerebral cavernous malformation
653 a endothelial cells
653 a beta-catenin
653 a sulindac metabolites
653 a vascular pathology
7001 a Rudini, Noemi4 aut
7001 a Cuttano, Roberto4 aut
7001 a Giampietro, Costanza4 aut
7001 a Maddaluno, Luigi4 aut
7001 a Ferrarini, Luca4 aut
7001 a Adams, Ralf H.4 aut
7001 a Corada, Monica4 aut
7001 a Boulday, Gwenola4 aut
7001 a Tournier-Lasserve, Elizabeth4 aut
7001 a Dejana, Elisabettau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)elide443
7001 a Lampugnani, Maria Grazia4 aut
7102 a Uppsala universitetb Vaskulärbiologi4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 112:27, s. 8421-8426q 112:27<8421-8426x 0027-8424x 1091-6490
8564 u https://www.pnas.org/content/pnas/112/27/8421.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259652
8564 8u https://doi.org/10.1073/pnas.1501352112

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy