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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003228naa a2200409 4500
001oai:prod.swepub.kib.ki.se:127697589
003SwePub
008240701s2013 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1276975892 URI
0247 a https://doi.org/10.2500/ajra.2013.27.39222 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Katotomichelakis, M4 aut
2451 0a Inflammatory patterns in upper airway disease in the same geographical area may change over time
264 c 2013-09-01
264 1b SAGE Publications,c 2013
520 a Inflammatory patterns of nasal polyps (NPs) may vary. Changes over time have not been investigated so far. This study was designed to evaluate the inflammatory patterns of NPs in Thailand at two time points 12 years apart, explore differences in Staphylococcus aureus (SA) mucosal carriage rates over time, and the latter's relationship with the inflammatory patterns. Methods Formalin-fixed nasal tissue was obtained from 89 (47 in 1999 and 42 in 2011) patients suffering from chronic rhinosinusitis with NPs (CRSwNPs). Tissues were evaluated for eosinophils, neutrophils, IgE+ cells, IgE and macrophage mannose receptors, interleukin (IL)-5 and IL-17 cytokine profile, and the presence of SA, using automated immunohistochemistry and peptide nucleic acid–fluorescence in situ hybridization. Results We found a significant increase in the absolute values of eosinophils and IgE+ cells in the 2011 CRSwNP tissue series compared with 1999 and a significant but smaller increase in neutrophils. Semiquantitative evaluation revealed significantly higher mean values of positive cells for all studied inflammatory markers in the 2011 group of patients, except for the high-affinity IgE receptor. This “eosinophilic shift” of inflammation was accompanied by higher SA carriage, as well as higher frequencies of SA invasion (54.8% versus 10.6%; p < 0.001) in the 2011 compared with 1999 subjects. Patients with asthma were more likely to have higher SA carriage rates compared with nonasthmatic patients. Conclusion There was a shift from predominantly neutrophilic to eosinophilic CRSwNPs in Thai patients within 12 years, with an increase in various inflammatory markers including IgE, which is associated with an increase in intramucosal presence of SA.
7001 a Tantilipikorn, P4 aut
7001 a Holtappels, G4 aut
7001 a De Ruyck, N4 aut
7001 a Feng, L4 aut
7001 a Van Zele, T4 aut
7001 a Muangsomboon, S4 aut
7001 a Jareonchasri, P4 aut
7001 a Bunnag, C4 aut
7001 a Danielides, V4 aut
7001 a Cuvelier, CA4 aut
7001 a Hellings, PW4 aut
7001 a Bachert, Cu Karolinska Institutet4 aut
7001 a Zhang, N4 aut
7102 a Karolinska Institutet4 org
7730 t American journal of rhinology & allergyd : SAGE Publicationsg 27:5, s. 354-360q 27:5<354-360x 1945-8932x 1945-8924
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:127697589
8564 8u https://doi.org/10.2500/ajra.2013.27.3922

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