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Axon morphology is ...
Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship
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- Andersson, Mariam (författare)
- Technical University of Denmark,Hvidovre Hospital
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- Kjer, Hans Martin (författare)
- Technical University of Denmark,Hvidovre Hospital
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- Rafael-Patino, Jonathan (författare)
- Swiss Federal Institute of Technology
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- Pacureanu, Alexandra (författare)
- European Synchrotron Radiation Facility
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- Pakkenberg, Bente (författare)
- Copenhagen University Hospital
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- Thiran, Jean Philippe (författare)
- Lausanne University Hospital,Swiss Federal Institute of Technology,University of Lausanne
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- Ptito, Maurice (författare)
- University Of Quebec In Montreal,University of Copenhagen
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- Bech, Martin (författare)
- Lund University,Lunds universitet,X-ray Phase Contrast,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Bjorholm Dahl, Anders (författare)
- Technical University of Denmark
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- Andersen Dahl, Vedrana (författare)
- Technical University of Denmark
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- Dyrby, Tim B. (författare)
- Technical University of Denmark,Hvidovre Hospital
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(creator_code:org_t)
- 2020-12-21
- 2020
- Engelska 11 s.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 117:52, s. 33649-33659
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.pnas.org...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a monkey brain reveal that blood vessels, cells, and vacuoles affect axonal diameter and trajectory. Within single axons, we find that the variation in diameter and conduction velocity correlates with the mean diameter, contesting the value of precise diameter determination in larger axons. These complex 3D axon morphologies drive previously reported 2D trends in axon diameter and g-ratio. Furthermore, we find that these morphologies bias the estimates of axon diameter with diffusion magnetic resonance imaging and, ultimately, impact the investigation and formulation of the axon structure-function relationship.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- axon morphology
- brain
- conduction velocity
- MRI
- myelination
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Andersson, Maria ...
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Kjer, Hans Marti ...
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Rafael-Patino, J ...
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Pacureanu, Alexa ...
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Pakkenberg, Bent ...
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Thiran, Jean Phi ...
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Ptito, Maurice
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Bech, Martin
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Bjorholm Dahl, A ...
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Andersen Dahl, V ...
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Dyrby, Tim B.
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