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Identification of a...
Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
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- Debortoli, Guilherme (författare)
- Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada
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- de Araujo, Gilderlanio Santana (författare)
- Program in Genetics and Molecular Biology, Federal University of Pará, Belém, Brazil
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- Fortes-Lima, Cesar A., PhD, 1985- (författare)
- Uppsala universitet,Människans evolution
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- Parra, Esteban J (författare)
- Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada
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- Suarez-Kurtz, Guilherme (författare)
- Instituto Nacional de Câncer and Rede Nacional de Farmacogenética, Rio de Janeiro, Brazil
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(creator_code:org_t)
- 2021-01-13
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- Biologi med inriktning mot människans evolution och genetik
- Biology with Specialisation in Human Evolution and Genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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