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Sökning: WFRF:(Douglas Pamela S.) > (2005-2009) > Alcohol Intake and ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004497naa a2200661 4500
001oai:DiVA.org:uu-148429
003SwePub
008110307s2009 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:118414968
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1484292 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-08-08802 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1184149682 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Genkinger, Jeanine M.4 aut
2451 0a Alcohol Intake and Pancreatic Cancer Risk :b A Pooled Analysis of Fourteen Cohort Studies
264 1c 2009
338 a print2 rdacarrier
520 a Background: Few risk factors have been implicated in pancreatic cancer etiology. Alcohol has been theorized to promote carcinogenesis. However, epidemiologic studies have reported inconsistent results relating alcohol intake to pancreatic cancer risk. Methods: We conducted a pooled analysis of the primary data from 14 prospective cohort studies. The study sample consisted of 862,664 individuals among whom 2,187 incident pancreatic cancer cases were identified. Study-specific relative risks and 95% confidence intervals were calculated using Cox proportional hazards models and then pooled using a random effects model. Results: A slight positive association with pancreatic cancer risk was observed for alcohol intake (pooled multivariate relative risk, 1.22; 95% confidence interval, 1.03-1.45 comparing >= 30 to 0 grams/day of alcohol; P value, test for between-studies heterogeneity = 0.80). For this comparison, the positive association was only statistically significant among women although the difference in the results by gender was not statistically significant (P value, test for interaction = 0.19). Slightly stronger results for alcohol intake were observed when we limited the analysis to cases with adenocarcinomas of the pancreas. No statistically significant associations were observed for alcohol from wine, beer, and spirits comparing intakes of >= 5 to 0 grams/day. A stronger positive association between alcohol consumption and pancreatic cancer risk was observed among normal weight individuals compared with overweight and obese individuals (P value, test for interaction = 0.01). Discussion: Our findings are consistent with a modest increase in risk of pancreatic cancer with consumption of 30 or more grams of alcohol per day. (Cancer Epidemiol Biomarkers Prev 2009;18(3):765-76)
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Oncology
653 a Onkologi
7001 a Spiegelman, Donna4 aut
7001 a Anderson, Kristin E.4 aut
7001 a Bergkvist, Leifu Uppsala universitet,Centrum för klinisk forskning, Västerås4 aut0 (Swepub:uu)leber451
7001 a Bernstein, Leslie4 aut
7001 a van den Brandt, Piet A.4 aut
7001 a English, Dallas R.4 aut
7001 a Freudenheim, Jo L.4 aut
7001 a Fuchs, Charles S.4 aut
7001 a Giles, Graham G.4 aut
7001 a Giovannucci, Edward4 aut
7001 a Hankinson, Susan E.4 aut
7001 a Horn-Ross, Pamela L.4 aut
7001 a Leitzmann, Michael4 aut
7001 a Mannisto, Satu4 aut
7001 a Marshall, James R.4 aut
7001 a McCullough, Marjorie L.4 aut
7001 a Miller, Anthony B.4 aut
7001 a Reding, Douglas J.4 aut
7001 a Robien, Kim4 aut
7001 a Rohan, Thomas E.4 aut
7001 a Schatzkin, Arthur4 aut
7001 a Stevens, Victoria L.4 aut
7001 a Stolzenberg-Solomon, Rachael Z.4 aut
7001 a Verhage, Bas A. J.4 aut
7001 a Wolk, Alicjau Karolinska Institutet4 aut
7001 a Ziegler, Regina G.4 aut
7001 a Smith-Warner, Stephanie A.4 aut
7102 a Uppsala universitetb Centrum för klinisk forskning, Västerås4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiong 18:3, s. 765-776q 18:3<765-776x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-148429
8564 8u https://doi.org/10.1158/1055-9965.EPI-08-0880
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:118414968

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