WFRF:(Enerbäck Charlotta 1965 )
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04302naa a2200385 4500 | |
| 001 | oai:DiVA.org:liu-174353 | |
| 003 | SwePub | |
| 008 | 210320s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1743532 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jid.2020.07.0122 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Verma, Deepti,d 1969-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Centre4 aut0 (Swepub:liu)deeve22 |
| 245 | 1 0 | a Enhanced Inflammasome Activity in Patients with Psoriasis Promotes Systemic Inflammation |
| 264 | 1 | b Elsevier,c 2021 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding agencies: Ingrid Asp Foundation, the Edvard Welander Foundation, the Swedish Psoriasis Association, and the Medical Research Council of Southeast Sweden. | |
| 520 | a Psoriasis is linked to systemic inflammation and cardiovascular comorbidities, but studies of the underlying cellular mechanisms are lacking. The NLRP3 inflammasome is genetically associated with psoriasis, and its activation is increasingly linked with cardiovascular disease. In this study, we show that patients with psoriasis exhibited higher plasma levels of inflammasome-generated IL-1ß and IL-18, without any correlation to skin lesion severity. Increased constitutive expression of the inflammasome sensors NLRP3, NLRP1, and AIM2 was found in peripheral blood cells of the patients and also of those with mild disease, and this was accompanied by an increased caspase-1 reactivity in the myeloid blood subsets. TNF-a was found to activate selectively the NLRP3 inflammasome without the requirement for a priming signal. TNF-a was found to signal through the TNFR?caspase-8?caspase-1 alternative inflammasome pathway, which proceeds independently of pyroptosis. Patients who received anti-TNF therapy had normalized plasma IL-1ß and IL-18 levels as well as normalized caspase-1 reactivity. This was in contrast to the patients treated with methotrexate who exhibited persistent, increased caspase-1 reactivity. Thus, we show that the TNF-a-mediated activation of NLRP3 inflammasomes in patients with psoriasis may contribute to systemic inflammation. Anti-TNF therapy normalized inflammasome function, suggesting a mechanism for the cardiovascular risk?reducing effect. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 700 | 1 | a Zamani Fekri, Shorau Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Centre4 aut0 (Swepub:liu)shoza26 |
| 700 | 1 | a Sigurdardottir, Gunnthorunn,d 1975-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Centre4 aut0 (Swepub:liu)gunsi16 |
| 700 | 1 | a Bivik, Cecilia,d 1978-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Centre4 aut0 (Swepub:liu)cecbi55 |
| 700 | 1 | a Sandin, Charlotta,d 1976-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Centre4 aut0 (Swepub:liu)chasa61 |
| 700 | 1 | a Enerbäck, Charlotta,d 1965-u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Centre4 aut0 (Swepub:liu)chaen00 |
| 710 | 2 | a Linköpings universitetb Avdelningen för cellbiologi4 org |
| 773 | 0 | t Journal of Investigative Dermatologyd : Elsevierg 141:3, s. 586-595.e5q 141:3<586-595.e5x 0022-202Xx 1523-1747 |
| 856 | 4 | u https://doi.org/10.1016/j.jid.2020.07.012y Fulltext |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1538667/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://www.jidonline.org/article/S0022202X20319436/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174353 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jid.2020.07.012 |
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