Amoxicillin added to omeprazole prevents relapse in the treatment of duodenal ulcer patients

(creator_code:org_t)

1993
1993
Engelska.
Ingår i: European Journal of Gastroenterology and Hepathology. - 0954-691X .- 1473-5687. ; 5:5, s. 325-332

Abstract Ämnesord

Stäng

Objective: To evaluate two different therapies, omeprazole/amoxicillin versus omepra-zole alone, in the treatment of duodenal ulcer patients with respect to eradication of Helicobacter pylori and time in remission during a 6-month follow-up after cessation of therapy.Design: Double-blind, randomized, parallel groups.Setting: Outpatient referrals in nine Swedish centres.Patients: This study included 248 patients with active duodenal ulcer.Main outcome measures: Endoscopic and symptomatic evaluation of time in remission. Culture, histology and serology for determination of H. pylori status.Results: Eradication of H. pylori was 54 compared with 4% and the proportion of patients in remission at 6 months was 70 compared with 36% in the omeprazole/amoxicillin treated group versus the group treated with omeprazole alone. Of the patients who became H. pylori-negative, 84% were in remission throughout the study.Conclusion: H. pylori is an almost obligate prerequisite for duodenal ulcer disease. Amoxicillin added to omeprazole nearly doubled the proportion of patients in remission at 6 months follow-up. The eradication rate of H. pylori in patients with excellent compliance was 74%.

Av författaren/redakt...: Unge, Peter; Gad, Adel; Eriksson, Karin; Bergman, Börje; Carling, Lasse; Ekström, Per; visa fler...; Glise, Hans; Gnarpe, Håkan; Ljunghard, Ola; Lindholmer, Chri ...; Sandzén, Birger; Strandberg, Lars; Stubberöd, Arild; Weywadt, Lars; visa färre...

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