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Sökning: WFRF:(Escarcega Ricardo O.) > (2014) > A Systematic Review...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003978naa a2200541 4500
001oai:DiVA.org:uu-228219
003SwePub
008140708s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2282192 URI
0247 a https://doi.org/10.1016/j.amjcard.2014.01.4362 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lipinski, Michael J.4 aut
2451 0a A Systematic Review and Collaborative Meta-Analysis to Determine the Incremental Value of Copeptin for Rapid Rule-Out of Acute Myocardial Infarction
264 1b Elsevier BV,c 2014
338 a print2 rdacarrier
520 a Multiple studies have evaluated copeptin, a surrogate for arginine vasopressin, in the diagnosis of acute myocardial infarction (AMI) with mixed results. A systematic review and collaborative meta-analysis were performed for diagnosis of AMI and assessment of prognosis in patients presenting to the emergency department with chest pain. MEDLINE/PubMed, Cochrane CENTRAL, and EMBASE were searched for studies assessing copeptin in such patients. Study investigators were contacted, and many provided previously unpublished data. Random-effects methods were used to compare the data for copeptin, troponin, and their combination. There were a total of 9,244 patients from the 14 included studies. Mean age was 62 years; 64% were men; and 18.4% were ultimately diagnosed with AMI. Patients with AMI had a higher presentation copeptin level than those without AMI (22.8 vs 8.3 pmol/L, respectively, p <0.001). Although troponin had better diagnostic accuracy than copeptin for AMI, the combination of copeptin and troponin significantly improved the sensitivity (0.905 [0.888 to 0.921] vs 0.686 [0.661 to 0.710], respectively, p <0.001) and negative predictive value (0.97 [0.964 to 0.975] vs 0.93 [0.924 to 0.936], respectively, p <0.001) compared with troponin alone. Elevation in copeptin carried a similar risk of all-cause mortality to an elevation in troponin (odds ratio 5.84 vs 6.74, respectively, p = 0.67). In conclusion, copeptin not only identifies patients at risk of all-cause mortality, but its addition to troponin improved the sensitivity and negative likelihood ratio for diagnosis of AMI compared with troponin alone. Thus, copeptin may help identify patients who may be safely discharged early from the emergency department.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Escarcega, Ricardo O.4 aut
7001 a D'Ascenzo, Fabrizio4 aut
7001 a Magalhaes, Marco A.4 aut
7001 a Baker, Nevin C.4 aut
7001 a Torguson, Rebecca4 aut
7001 a Chen, Fang4 aut
7001 a Epstein, Stephen E.4 aut
7001 a Miro, Oscar4 aut
7001 a Llorens, Pere4 aut
7001 a Giannitsis, Evangelos4 aut
7001 a Lotze, Ulrich4 aut
7001 a Lefebvre, Sophie4 aut
7001 a Sebbane, Mustapha4 aut
7001 a Cristol, Jean-Paul4 aut
7001 a Chenevier-Gobeaux, Camille4 aut
7001 a Meune, Christophe4 aut
7001 a Eggers, Kai M.u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)kaieg561
7001 a Charpentier, Sandrine4 aut
7001 a Twerenbold, Raphael4 aut
7001 a Mueller, Christian4 aut
7001 a Biondi-Zoccai, Giuseppe4 aut
7001 a Waksman, Ron4 aut
7102 a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t American Journal of Cardiologyd : Elsevier BVg 113:9, s. 1581-1591q 113:9<1581-1591x 0002-9149x 1879-1913
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228219
8564 8u https://doi.org/10.1016/j.amjcard.2014.01.436

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