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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08961naa a2202077 4500 | |
| 001 | oai:gup.ub.gu.se/296353 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:153509860 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2963532 URI |
| 024 | 7 | a https://doi.org/10.1038/s41380-020-0754-02 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1535098602 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
| 245 | 1 0 | a Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group |
| 264 | c 2020-05-18 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. © 2020, The Author(s). | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 700 | 1 | a Dinga, R.4 aut |
| 700 | 1 | a Hahn, T.4 aut |
| 700 | 1 | a Ching, C. R. K.4 aut |
| 700 | 1 | a Eyler, L. T.4 aut |
| 700 | 1 | a Aftanas, L.4 aut |
| 700 | 1 | a Aghajani, M.4 aut |
| 700 | 1 | a Aleman, A.4 aut |
| 700 | 1 | a Baune, B. T.4 aut |
| 700 | 1 | a Berger, K.4 aut |
| 700 | 1 | a Brak, I.4 aut |
| 700 | 1 | a Filho, G. B.4 aut |
| 700 | 1 | a Carballedo, A.u Karolinska Institutet4 aut |
| 700 | 1 | a Connolly, C. G.4 aut |
| 700 | 1 | a Couvy-Duchesne, B.4 aut |
| 700 | 1 | a Cullen, K. R.4 aut |
| 700 | 1 | a Dannlowski, U.4 aut |
| 700 | 1 | a Davey, C. G.4 aut |
| 700 | 1 | a Dima, D.4 aut |
| 700 | 1 | a Duran, F. L. S.4 aut |
| 700 | 1 | a Enneking, V.4 aut |
| 700 | 1 | a Filimonova, E.4 aut |
| 700 | 1 | a Frenzel, S.4 aut |
| 700 | 1 | a Frodl, T.4 aut |
| 700 | 1 | a Fu, C. H. Y.4 aut |
| 700 | 1 | a Godlewska, B. R.4 aut |
| 700 | 1 | a Gotlib, I. H.4 aut |
| 700 | 1 | a Grabe, H. J.4 aut |
| 700 | 1 | a Groenewold, N. A.4 aut |
| 700 | 1 | a Grotegerd, D.4 aut |
| 700 | 1 | a Gruber, O.4 aut |
| 700 | 1 | a Hall, G. B.4 aut |
| 700 | 1 | a Harrison, B. J.4 aut |
| 700 | 1 | a Hatton, S. N.4 aut |
| 700 | 1 | a Hermesdorf, M.4 aut |
| 700 | 1 | a Hickie, I. B.4 aut |
| 700 | 1 | a Ho, T. C.4 aut |
| 700 | 1 | a Hosten, N.4 aut |
| 700 | 1 | a Jansen, A.4 aut |
| 700 | 1 | a Kähler, C.4 aut |
| 700 | 1 | a Kircher, T.4 aut |
| 700 | 1 | a Klimes-Dougan, B.4 aut |
| 700 | 1 | a Krämer, B.4 aut |
| 700 | 1 | a Krug, A.4 aut |
| 700 | 1 | a Lagopoulos, J.4 aut |
| 700 | 1 | a Leenings, R.4 aut |
| 700 | 1 | a MacMaster, F. P.4 aut |
| 700 | 1 | a MacQueen, G.4 aut |
| 700 | 1 | a McIntosh, A.4 aut |
| 700 | 1 | a McLellan, Q.4 aut |
| 700 | 1 | a McMahon, K. L.4 aut |
| 700 | 1 | a Medland, S. E.4 aut |
| 700 | 1 | a Mueller, B. A.4 aut |
| 700 | 1 | a Mwangi, B.4 aut |
| 700 | 1 | a Osipov, E.4 aut |
| 700 | 1 | a Portella, M. J.4 aut |
| 700 | 1 | a Pozzi, E.4 aut |
| 700 | 1 | a Reneman, L.4 aut |
| 700 | 1 | a Repple, J.4 aut |
| 700 | 1 | a Rosa, P. G. P.4 aut |
| 700 | 1 | a Sacchet, M. D.4 aut |
| 700 | 1 | a Sämann, P. G.4 aut |
| 700 | 1 | a Schnell, K.4 aut |
| 700 | 1 | a Schrantee, A.4 aut |
| 700 | 1 | a Simulionyte, E.4 aut |
| 700 | 1 | a Soares, J. C.4 aut |
| 700 | 1 | a Sommer, J.4 aut |
| 700 | 1 | a Stein, D. J.4 aut |
| 700 | 1 | a Steinsträter, O.4 aut |
| 700 | 1 | a Strike, L. T.4 aut |
| 700 | 1 | a Thomopoulos, S. I.4 aut |
| 700 | 1 | a van Tol, M. J.4 aut |
| 700 | 1 | a Veer, I. M.u Karolinska Institutet4 aut |
| 700 | 1 | a Vermeiren, R. R. J. M.4 aut |
| 700 | 1 | a Walter, H.4 aut |
| 700 | 1 | a van der Wee, N. J. A.4 aut |
| 700 | 1 | a van der Werff, S. J. A.4 aut |
| 700 | 1 | a Whalley, H.4 aut |
| 700 | 1 | a Winter, N. R.4 aut |
| 700 | 1 | a Wittfeld, K.4 aut |
| 700 | 1 | a Wright, M. J.4 aut |
| 700 | 1 | a Wu, M. J.4 aut |
| 700 | 1 | a Völzke, H.4 aut |
| 700 | 1 | a Yang, T. T.4 aut |
| 700 | 1 | a Zannias, V.4 aut |
| 700 | 1 | a de Zubicaray, G. I.4 aut |
| 700 | 1 | a Zunta-Soares, G. B.4 aut |
| 700 | 1 | a Abé, C.4 aut |
| 700 | 1 | a Alda, M.4 aut |
| 700 | 1 | a Andreassen, O. A.4 aut |
| 700 | 1 | a Bøen, E.4 aut |
| 700 | 1 | a Bonnin, C. M.4 aut |
| 700 | 1 | a Canales-Rodriguez, E. J.4 aut |
| 700 | 1 | a Cannon, D.4 aut |
| 700 | 1 | a Caseras, X.4 aut |
| 700 | 1 | a Chaim-Avancini, T. M.4 aut |
| 700 | 1 | a Elvsåshagen, T.4 aut |
| 700 | 1 | a Favre, P.4 aut |
| 700 | 1 | a Foley, S. F.4 aut |
| 700 | 1 | a Fullerton, J. M.4 aut |
| 700 | 1 | a Goikolea, J. M.4 aut |
| 700 | 1 | a Haarman, B. C. M.4 aut |
| 700 | 1 | a Hajek, T.4 aut |
| 700 | 1 | a Henry, C.4 aut |
| 700 | 1 | a Houenou, J.4 aut |
| 700 | 1 | a Howells, F. M.4 aut |
| 700 | 1 | a Ingvar, M.4 aut |
| 700 | 1 | a Kuplicki, R.4 aut |
| 700 | 1 | a Lafer, B.4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Machado-Vieira, R.4 aut |
| 700 | 1 | a Malt, U. F.4 aut |
| 700 | 1 | a McDonald, C.4 aut |
| 700 | 1 | a Mitchell, P. B.4 aut |
| 700 | 1 | a Nabulsi, L.4 aut |
| 700 | 1 | a Otaduy, M. C. G.4 aut |
| 700 | 1 | a Overs, B. J.4 aut |
| 700 | 1 | a Polosan, M.4 aut |
| 700 | 1 | a Pomarol-Clotet, E.4 aut |
| 700 | 1 | a Radua, J.4 aut |
| 700 | 1 | a Rive, M. M.4 aut |
| 700 | 1 | a Roberts, G.4 aut |
| 700 | 1 | a Ruhe, H. G.4 aut |
| 700 | 1 | a Salvador, R.4 aut |
| 700 | 1 | a Sarró, S.4 aut |
| 700 | 1 | a Satterthwaite, T. D.4 aut |
| 700 | 1 | a Savitz, J.4 aut |
| 700 | 1 | a Schene, A. H.4 aut |
| 700 | 1 | a Schofield, P. R.4 aut |
| 700 | 1 | a Serpa, M. H.4 aut |
| 700 | 1 | a Sim, K.4 aut |
| 700 | 1 | a Soeiro-de-Souza, M. G.4 aut |
| 700 | 1 | a Sutherland, A. N.4 aut |
| 700 | 1 | a Temmingh, H. S.4 aut |
| 700 | 1 | a Timmons, G. M.4 aut |
| 700 | 1 | a Uhlmann, A.4 aut |
| 700 | 1 | a Vieta, E.4 aut |
| 700 | 1 | a Wolf, D. H.4 aut |
| 700 | 1 | a Zanetti, M. V.4 aut |
| 700 | 1 | a Jahanshad, N.4 aut |
| 700 | 1 | a Thompson, P. M.4 aut |
| 700 | 1 | a Veltman, D. J.4 aut |
| 700 | 1 | a Penninx, B. W. J. H.4 aut |
| 700 | 1 | a Marquand, A. F.4 aut |
| 700 | 1 | a Cole, J. H.4 aut |
| 700 | 1 | a Schmaal, L.4 aut |
| 700 | 1 | a Thomopoulos, IT4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Molecular Psychiatryd : Springer Science and Business Media LLCg 26, s. 5124-5139q 26<5124-5139x 1359-4184x 1476-5578 |
| 856 | 4 | u https://www.nature.com/articles/s41380-020-0754-0.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/296353 |
| 856 | 4 8 | u https://doi.org/10.1038/s41380-020-0754-0 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153509860 |
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