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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03931naa a2200925 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:147287278 | |
| 003 | SwePub | |
| 008 | 240811s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1472872782 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-021-24334-y2 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Pluta, J4 aut |
| 245 | 1 0 | a Identification of 22 susceptibility loci associated with testicular germ cell tumors |
| 264 | c 2021-07-23 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men with a polygenic risk score (PRS) in the 95th percentile have a 6.8-fold increased risk of TGCT compared to men with median scores. Among men with independent TGCT risk factors such as cryptorchidism, the PRS may guide screening decisions with the goal of reducing treatment-related complications causing long-term morbidity in survivors. These findings emphasize the interconnected nature of two known pathways that promote TGCT susceptibility: male germ cell development within its somatic niche and regulation of chromosomal division and structure, and implicate an additional biological pathway, mRNA translation. | |
| 700 | 1 | a Pyle, LC4 aut |
| 700 | 1 | a Nead, KT4 aut |
| 700 | 1 | a Wilf, R4 aut |
| 700 | 1 | a Li, MY4 aut |
| 700 | 1 | a Mitra, N4 aut |
| 700 | 1 | a Weathers, B4 aut |
| 700 | 1 | a D'Andrea, K4 aut |
| 700 | 1 | a Almstrup, K4 aut |
| 700 | 1 | a Anson-Cartwright, L4 aut |
| 700 | 1 | a Benitez, J4 aut |
| 700 | 1 | a Brown, CD4 aut |
| 700 | 1 | a Chanock, S4 aut |
| 700 | 1 | a Chen, C4 aut |
| 700 | 1 | a Cortessis, VK4 aut |
| 700 | 1 | a Ferlin, A4 aut |
| 700 | 1 | a Foresta, C4 aut |
| 700 | 1 | a Gamulin, M4 aut |
| 700 | 1 | a Gietema, JA4 aut |
| 700 | 1 | a Grasso, C4 aut |
| 700 | 1 | a Greene, MH4 aut |
| 700 | 1 | a Grotmol, T4 aut |
| 700 | 1 | a Hamilton, RJ4 aut |
| 700 | 1 | a Haugen, TB4 aut |
| 700 | 1 | a Hauser, R4 aut |
| 700 | 1 | a Hildebrandt, MAT4 aut |
| 700 | 1 | a Johnson, ME4 aut |
| 700 | 1 | a Karlsson, Ru Karolinska Institutet4 aut |
| 700 | 1 | a Kiemeney, LA4 aut |
| 700 | 1 | a Lessel, D4 aut |
| 700 | 1 | a Lothe, RA4 aut |
| 700 | 1 | a Loud, JT4 aut |
| 700 | 1 | a Loveday, C4 aut |
| 700 | 1 | a Martin-Gimeno, P4 aut |
| 700 | 1 | a Meijer, C4 aut |
| 700 | 1 | a Nsengimana, J4 aut |
| 700 | 1 | a Quinn, DI4 aut |
| 700 | 1 | a Rafnar, T4 aut |
| 700 | 1 | a Ramdas, S4 aut |
| 700 | 1 | a Richiardi, L4 aut |
| 700 | 1 | a Skotheim, RI4 aut |
| 700 | 1 | a Stefansson, K4 aut |
| 700 | 1 | a Turnbull, C4 aut |
| 700 | 1 | a Vaughn, DJ4 aut |
| 700 | 1 | a Wiklund, Fu Karolinska Institutet4 aut |
| 700 | 1 | a Wu, XF4 aut |
| 700 | 1 | a Yang, D4 aut |
| 700 | 1 | a Zheng, T4 aut |
| 700 | 1 | a Wells, AD4 aut |
| 700 | 1 | a Grant, SFA4 aut |
| 700 | 1 | a Rajpert-De Meyts, E4 aut |
| 700 | 1 | a Schwartz, SM4 aut |
| 700 | 1 | a Bishop, DT4 aut |
| 700 | 1 | a McGlynn, KA4 aut |
| 700 | 1 | a Kanetsky, PA4 aut |
| 700 | 1 | a Nathanson, KL4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 12:1, s. 4487-q 12:1<4487-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-021-24334-y.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147287278 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-021-24334-y |
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- Pluta, J
- Pyle, LC
- Nead, KT
- Wilf, R
- Li, MY
- Mitra, N
- visa fler...
- Weathers, B
- D'Andrea, K
- Almstrup, K
- Anson-Cartwright ...
- Benitez, J
- Brown, CD
- Chanock, S
- Chen, C
- Cortessis, VK
- Ferlin, A
- Foresta, C
- Gamulin, M
- Gietema, JA
- Grasso, C
- Greene, MH
- Grotmol, T
- Hamilton, RJ
- Haugen, TB
- Hauser, R
- Hildebrandt, MAT
- Johnson, ME
- Karlsson, R
- Kiemeney, LA
- Lessel, D
- Lothe, RA
- Loud, JT
- Loveday, C
- Martin-Gimeno, P
- Meijer, C
- Nsengimana, J
- Quinn, DI
- Rafnar, T
- Ramdas, S
- Richiardi, L
- Skotheim, RI
- Stefansson, K
- Turnbull, C
- Vaughn, DJ
- Wiklund, F
- Wu, XF
- Yang, D
- Zheng, T
- Wells, AD
- Grant, SFA
- Rajpert-De Meyts ...
- Schwartz, SM
- Bishop, DT
- McGlynn, KA
- Kanetsky, PA
- Nathanson, KL
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