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Sökning: WFRF:(Fossum Eigil) > (2021) > The Full Revasc (Ff...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005564naa a2200529 4500
001oai:DiVA.org:uu-458518
003SwePub
008211111s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147921404
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4585182 URI
0247 a https://doi.org/10.1016/j.ahj.2021.07.0072 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1479214042 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Böhm, Felixu Karolinska Institutet,Karolinska Inst, Dept Cardiol, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.4 aut
2451 0a The Full Revasc (Ffr-gUidance for compLete non-cuLprit REVASCularization) Registry-based randomized clinical trial
264 1b Elsevier,c 2021
338 a electronic2 rdacarrier
520 a Background Complete revascularization in ST elevation myocardial infarction (STEMI) patients with multivessel disease has resulted in reduction in composite clinical endpoints in medium sized trials. Only one trial showed an effect on hard clinical endpoints, but the revascularization procedure was guided by angiographic evaluation of stenosis severity. Consequently, it is not clear how Fractional Flow Reserve (FFR)-guided percutaneous coronary intervention (PCI) affects hard clinical endpoints in STEMI. Methods and Results The Ffr-gUidance for compLete non-cuLprit REVASCularization (FULL REVASC) - is a pragmatic, multicenter, international, registry-based randomized clinical trial designed to evaluate whether a strategy of FFR-guided complete revascularization of non-culprit lesions, reduces the combined primary endpoint of total mortality, non-fatal MI and unplanned revascularization. 1,545 patients were randomized to receive FFR-guided PCI during the index hospitalization or initial conservative management of non-culprit lesions. We found that in angiographically severe non-culprit lesions of 90-99% severity, 1 in 5 of these lesions were re-classified as non-flow limiting by FFR. Considering lesions of intermediate severity (70%-89%), half were re-classified as non-flow limiting by FFR. The study is event driven for an estimated follow-up of at least 2.75 years to detect a 9.9%/year >7.425%/year difference (HR = 0.74 at 80% power (alpha = .05)) for the combined primary endpoint. Conclusion This large randomized clinical trial is designed and powered to evaluate the effect of complete revascularization with FFR-guided PCI during index hospitalization on total mortality, non-fatal MI and unplanned revascularization following primary PCI in STEMI patients with multivessel disease. Enrollment completed in September 2019 and follow-up is ongoing.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Mogensen, Brynjölfuru Karolinska Inst, Dept Cardiol, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.4 aut
7001 a Östlund, Ollieu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)oos27600
7001 a Engstrom, Thomasu Univ Copenhagen, Dept Cardiol, Rigshosp, Copenhagen, Denmark.4 aut
7001 a Fossum, Eigilu Univ Oslo, Ulleval Hosp, Dept Cardiol, Oslo, Norway.4 aut
7001 a Stankovic, Goranu Univ Belgrade, Univ Clin Ctr Serbia, Belgrade, Serbia.4 aut
7001 a Angerås, Oskaru Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.4 aut
7001 a Erglis, Andrejsu Univ Latvia, Latvian Ctr Cardiol, Pauls Stradins Clin Univ Hosp, Riga, Latvia.4 aut
7001 a Menon, Madhavu Waikato Hosp, Dept Cardiol, Hamilton, New Zealand.4 aut
7001 a Schultz, Carlu Univ Western Australia, Sch Med, Perth, WA, Australia.;Royal Perth Hosp, Dept Cardiol, Perth, WA, Australia.4 aut
7001 a Berry, Colinu Golden Jubilee Natl Hosp, West Scotland Reg Heart & Lung Ctr, Glasgow, Lanark, Scotland.;Univ Glasgow, Inst Cardiovasc & Med Sci, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland.4 aut
7001 a Liebetrau, Christophu Kerckhoff Heart & Thorax Ctr, Dept Cardiol, Bad Nauheim, Germany.;Univ Giessen, Div Cardiol, Dept Internal Med 1, Giessen, Germany.4 aut
7001 a Laine, Mikau Univ Helsinki, Abdominal Ctr, Dept Vasc Surg, Helsinki, Finland.4 aut
7001 a Held, Claes,d 1956-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)clahe947
7001 a Ruck, Andreasu Karolinska Institutet4 aut
7001 a James, Stefan K.,d 1964-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)stjam367
7102 a Karolinska Institutetb Karolinska Inst, Dept Cardiol, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.4 org
7730 t American Heart Journald : Elsevierg 241, s. 92-100q 241<92-100x 0002-8703x 1097-6744
8564 u https://doi.org/10.1016/j.ahj.2021.07.007y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1610540/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.ahj.2021.07.007
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458518
8564 8u https://doi.org/10.1016/j.ahj.2021.07.007
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147921404

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