WFRF:(Frangos Eleni)
Search: WFRF:(Frangos Eleni) > Innocuous pressure ...
- 1 of 2
- Previous record
- Next record
- To hitlist
Innocuous pressure sensation requires A-type afferents but not functional Rho Iota Epsilon Zeta Omicron 2 channels in humans
-
- Case, Laura K. (author)
- NIH, MD 20892 USA; Univ Calif San Diego, CA 92103 USA
-
- Liljencrantz, Jaquette (author)
- NIH, MD 20892 USA; Univ Gothenburg, Sweden
-
- Madian, Nicholas (author)
- NIH, MD 20892 USA
- show more...
- show less...
- (creator_code:org_t)
- 2021-01-28
- 2021
- English.
- In: Nature Communications. - : Nature Research. - 2041-1723. ; 12:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The sensation of pressure allows us to feel sustained compression and body strain. While our understanding of cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations of patients with rare sensory disorders, as well as nerve blocks in typical individuals, to probe the neural and genetic mechanisms for detecting non-painful pressure. We show that the ability to perceive innocuous pressures is lost when myelinated fiber function is experimentally blocked in healthy volunteers and that two patients lacking A beta fibers are strikingly unable to feel innocuous pressures at all. We find that seven individuals with inherited mutations in the mechanoreceptor PIEZO2 gene, who have major deficits in touch and proprioception, are nearly as good at sensing pressure as healthy control subjects. Together, these data support a role for A beta afferents in pressure sensation and suggest the existence of an unknown molecular pathway for its detection. The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking A beta fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Nature Communications (Search for host publication in LIBRIS)
To the university's database
- 1 of 2
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Case, Laura K.
- Liljencrantz, Ja ...
- Madian, Nicholas
- Necaise, Aaron
- Tubbs, Justin
- McCall, Micaela
- show more...
- Bradson, Megan L ...
- Szczot, Marcin
- Pitcher, Mark H.
- Ghitani, Nima
- Frangos, Eleni
- Cole, Jonathan
- Bharucha-Goebel, ...
- Saade, Dimah
- Ogata, Tracy
- Donkervoort, San ...
- Foley, A. Reghan
- Bonnemann, Carst ...
- Olausson, Håkan
- Bushnell, M. Cat ...
- Chesler, Alexand ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
- Articles in the publication
- Nature Communica ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
