Sökning: WFRF:(Frenck Robert W Jr)
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Serologic correlate...
Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea
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Rao, Malla (författare)
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Wierzba, Thomas (författare)
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Savarino, Stephen (författare)
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visa fler...
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Abu-Elyazeed, Remon (författare)
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El-Ghoreb, N. (författare)
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Hall, E. R. (författare)
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Naficy, Abdollah (författare)
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Abdel-Messih, I. (författare)
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Frenck, Robert W Jr (författare)
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- Svennerholm, Ann-Mari, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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- Clemens, John (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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visa färre...
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: J Infect Dis. ; 191:4, s. 562-70
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- BACKGROUND: We conducted a nested case-control study in 397 rural Egyptian children <36 months of age to assess the correlation between serum levels of antibodies against toxin and colonization factors (CFs) and the risk of homologous enterotoxigenic Escherichia coli (ETEC) diarrhea. METHODS: Active case detection was performed via semiweekly home visits, and blood was obtained at 3-month intervals. After each serosurvey, case subjects were selected from children experiencing a CF antigen (CFA)/I-, CFA/II-, CFA/IV-, or heat-labile enterotoxin (LT)-ETEC diarrheal episode during the subsequent 3 months. Up to 5 control subjects per case subject were selected from children who did not experience an ETEC diarrheal episode during the corresponding interval. Serum titers of immunoglobulin G antibodies against CFA/I, coli surface antigen (CS) 3, CS6, and LT were measured by enzyme-linked immunosorbant assay. RESULTS: The distribution of serum titers of LT, CS3, and CS6 antibodies did not differ between the case and control subjects. For children <18 months of age, serum titers of CFA/I antibody were inversely related to the risk of CFA/I-ETEC diarrhea; reciprocal serum titers of CFA/I antibody > or =76 were associated with a 77% reduction in the odds of CFA/I-ETEC diarrhea. CONCLUSION: Induction of reciprocal serum titers of antibodies against CFA/I within or above the 76-186 range should be further evaluated as a predictor for assessment of the ability of candidate vaccines to protect against CFA/I-ETEC diarrhea.
Nyckelord
- Antibodies
- Bacterial/*blood
- Bacterial Proteins/analysis/immunology
- Bacterial Toxins/analysis/*immunology
- Case-Control Studies
- Child
- Preschool
- Diarrhea/*microbiology/*prevention & control
- Egypt
- Enterotoxins/analysis/*immunology
- Enzyme-Linked Immunosorbent Assay
- Escherichia coli/*immunology/pathogenicity
- Escherichia coli Infections/*immunology/microbiology
- Escherichia coli Proteins/analysis/*immunology
- Female
- Fimbriae Proteins/analysis/immunology
- Humans
- Immunoglobulin G/blood
- Infant
- Male
- Virulence Factors/analysis/immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Rao, Malla
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Wierzba, Thomas
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Savarino, Stephe ...
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Abu-Elyazeed, Re ...
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El-Ghoreb, N.
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Hall, E. R.
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visa fler...
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Naficy, Abdollah
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Abdel-Messih, I.
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Frenck, Robert W ...
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Svennerholm, Ann ...
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Clemens, John
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- Artiklar i publikationen
- J Infect Dis
- Av lärosätet
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Göteborgs universitet