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WFRF:(Gardner Eugene J.)
 

Sökning: WFRF:(Gardner Eugene J.) > Reduced reproductiv...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003798naa a2200481 4500
001oai:DiVA.org:su-203445
003SwePub
008220411s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-513107
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2034452 URI
0247 a https://doi.org/10.1038/s41586-022-04549-92 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5131072 URI
040 a (SwePub)sud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gardner, Eugene J.4 aut
2451 0a Reduced reproductive success is associated with selective constraint on human genes
264 c 2022-03-23
264 1b Springer Science and Business Media LLC,c 2022
338 a print2 rdacarrier
520 a Genome-wide sequencing of human populations has revealed substantial variation among genes in the intensity of purifying selection acting on damaging genetic variants1. Although genes under the strongest selective constraint are highly enriched for associations with Mendelian disorders, most of these genes are not associated with disease and therefore the nature of the selection acting on them is not known2. Here we show that genetic variants that damage these genes are associated with markedly reduced reproductive success, primarily owing to increased childlessness, with a stronger effect in males than in females. We present evidence that increased childlessness is probably mediated by genetically associated cognitive and behavioural traits, which may mean that male carriers are less likely to find reproductive partners. This reduction in reproductive success may account for 20% of purifying selection against heterozygous variants that ablate protein-coding genes. Although this genetic association may only account for a very minor fraction of the overall likelihood of being childless (less than 1%), especially when compared to more influential sociodemographic factors, it may influence how genes evolve over time.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a SAMHÄLLSVETENSKAPx Sociologi0 (SwePub)5042 hsv//swe
650 7a SOCIAL SCIENCESx Sociology0 (SwePub)5042 hsv//eng
650 7a LANTBRUKSVETENSKAPERx Bioteknologi med applikationer på växter och djur0 (SwePub)4042 hsv//swe
650 7a AGRICULTURAL SCIENCESx Agricultural Biotechnology0 (SwePub)4042 hsv//eng
7001 a Neville, Matthew D. C.4 aut
7001 a Samocha, Kaitlin E.4 aut
7001 a Barclay, Kieron,d 1986-u Uppsala universitet,Stockholms universitet,Sociologiska institutionen,Max Planck Institute for Demographic Research, Germany; Swedish Collegium for Advanced Study, Sweden,Kollegiet för avancerade studier (SCAS),Max Planck Institute for Demographic Research, Rostock, Germany;Demography Unit, Department of Sociology, Stockholm University, Stockholm, Sweden4 aut0 (Swepub:su)kbarc
7001 a Kolk, Martin,d 1986-u Stockholms universitet,Sociologiska institutionen4 aut0 (Swepub:su)mkolk
7001 a Niemi, Mari E. K.4 aut
7001 a Kirov, George4 aut
7001 a Martin, Hilary C.4 aut
7001 a Hurles, Matthew E.4 aut
7102 a Stockholms universitetb Sociologiska institutionen4 org
7730 t Natured : Springer Science and Business Media LLCg 603:7903, s. 858-863q 603:7903<858-863x 0028-0836x 1476-4687
8564 u https://www.nature.com/articles/s41586-022-04549-9y Nature
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-203445
8564 8u https://doi.org/10.1038/s41586-022-04549-9
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-513107

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