WFRF:(Geneid A.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03061naa a2200553 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:236048924 | |
| 003 | SwePub | |
| 008 | 240124s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:153430503 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2360489242 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.22095141192 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1534305032 URI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kreutzberger, AJB4 aut |
| 245 | 1 0 | a SARS-CoV-2 requires acidic pH to infect cells |
| 264 | c 2022-09 | |
| 264 | 1 | b Proceedings of the National Academy of Sciences,c 2022 |
| 506 | a gratis | |
| 520 | a Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with membrane attachment and ends with spike (S) protein–catalyzed membrane fusion depending on two cleavage steps, namely, one usually by furin in producing cells and the second by TMPRSS2 on target cells. Endosomal cathepsins can carry out both. Using real-time three-dimensional single-virion tracking, we show that fusion and genome penetration require virion exposure to an acidic milieu of pH 6.2 to 6.8, even when furin and TMPRSS2 cleavages have occurred. We detect the sequential steps of S1-fragment dissociation, fusion, and content release from the cell surface in TMPRRS2-overexpressing cells only when exposed to acidic pH. We define a key role of an acidic environment for successful infection, found in endosomal compartments and at the surface of TMPRSS2-expressing cells in the acidic milieu of the nasal cavity. | |
| 700 | 1 | a Sanyal, A4 aut |
| 700 | 1 | a Saminathan, A4 aut |
| 700 | 1 | a Bloyet, LM4 aut |
| 700 | 1 | a Stumpf, S4 aut |
| 700 | 1 | a Liu, Z4 aut |
| 700 | 1 | a Ojha, R4 aut |
| 700 | 1 | a Patjas, MT4 aut |
| 700 | 1 | a Geneid, A4 aut |
| 700 | 1 | a Scanavachi, G4 aut |
| 700 | 1 | a Doyle, CA4 aut |
| 700 | 1 | a Somerville, E4 aut |
| 700 | 1 | a Correia, RBDC4 aut |
| 700 | 1 | a Di Caprio, G4 aut |
| 700 | 1 | a Toppila-Salmi, S4 aut |
| 700 | 1 | a Mäkitie, Au Karolinska Institutet4 aut |
| 700 | 1 | a Kiessling, V4 aut |
| 700 | 1 | a Vapalahti, O4 aut |
| 700 | 1 | a Whelan, SPJ4 aut |
| 700 | 1 | a Balistreri, G4 aut |
| 700 | 1 | a Kirchhausen, T4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 119:38, s. e2209514119-q 119:38<e2209514119-x 1091-6490 |
| 773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 119:38, s. e2209514119-q 119:38<e2209514119-x 0027-8424 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:236048924 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.2209514119 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153430503 |
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- Kreutzberger, AJ ...
- Sanyal, A
- Saminathan, A
- Bloyet, LM
- Stumpf, S
- Liu, Z
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- Ojha, R
- Patjas, MT
- Geneid, A
- Scanavachi, G
- Doyle, CA
- Somerville, E
- Correia, RBDC
- Di Caprio, G
- Toppila-Salmi, S
- Mäkitie, A
- Kiessling, V
- Vapalahti, O
- Whelan, SPJ
- Balistreri, G
- Kirchhausen, T
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