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Sökning: WFRF:(Genius Patricia) > (2023) > APOE -ε4 modulates ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008189naa a2200937 4500
001oai:lup.lub.lu.se:ea1185a4-af23-429b-bf82-28e93942b49f
003SwePub
008240112s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/ea1185a4-af23-429b-bf82-28e93942b49f2 URI
0247 a https://doi.org/10.1186/s13550-023-00967-62 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Brugulat-Serrat, Annau Hospital del Mar Medical Research Institute,Carlos III Health Institute,Global Brain Health Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
2451 0a APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
264 c 2023-03-01
264 1b Springer Science and Business Media LLC,c 2023
520 a Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), underwent [18F]flutemetamol Aβ positron emission tomography (PET), T1w magnetic resonance imaging (MRI), as well as APOE genotyping. Global and regional Aβ PET positivity was assessed across five regions-of-interest by visual reading (VR) and regional Centiloids. Linear regression models were developed to examine the interaction between regional and global Aβ PET positivity and APOE-ε4 status on longitudinal cognitive change assessed with the Preclinical Alzheimer’s Cognitive Composite (PACC), episodic memory, and executive function, after controlling for age, sex, education, cognitive baseline scores, and hippocampal volume. Results: In total, 57 participants (16.2%) were VR+ of whom 41 (71.9%) were APOE-ε4 carriers. No significant APOE-ε4*global Aβ PET interactions were associated with cognitive change for any cognitive test. However, APOE-ε4 carriers who were VR+ in temporal areas (n = 19 [9.81%], p = 0.04) and in the striatum (n = 8 [4.14%], p = 0.01) exhibited a higher decline in the PACC. The temporal areas findings were replicated when regional PET positivity was determined with Centiloid values. Regionally, VR+ in the striatum was associated with higher memory decline. As for executive function, interactions between APOE-ε4 and regional VR+ were found in temporal and parietal regions, and in the striatum. Conclusion: CU APOE-ε4 carriers with a positive Aβ PET VR in regions known to accumulate amyloid at later stages of the Alzheimer’s disease (AD) continuum exhibited a steeper cognitive decline. This work supports the contention that regional VR of Aβ PET might convey prognostic information about future cognitive decline in individuals at higher risk of developing AD. ClinicalTrials.gov Identifier: NCT02485730. Registered 20 June 2015 https://clinicaltrials.gov/ct2/show/NCT02485730 and ClinicalTrials.gov Identifier:NCT02685969. Registered 19 February 2016 https://clinicaltrials.gov/ct2/show/NCT02685969.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer’s disease
653 a Amyloid PET
653 a APOE-ε4
653 a Executive function
653 a Memory
653 a Visual read
7001 a Sánchez-Benavides, Gonzalou Hospital del Mar Medical Research Institute,Carlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Cacciaglia, Raffaeleu Pasqual Maragall Foundation for Research on Alzheimer,Carlos III Health Institute,Hospital del Mar Medical Research Institute4 aut
7001 a Salvadó, Gemmau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Pasqual Maragall Foundation for Research on Alzheimer4 aut0 (Swepub:lu)ge5655sa
7001 a Shekari, Mahnazu Pompeu Fabra University,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Collij, Lyduine E.u Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ly4120co
7001 a Buckley, Christopheru University College London4 aut
7001 a van Berckel, Bart N.M.u Vrije Universiteit Amsterdam4 aut
7001 a Perissinotti, Andrésu CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Hospital Clínic of Barcelona4 aut
7001 a Niñerola-Baizán, Aidau CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Hospital Clínic of Barcelona4 aut
7001 a Milà-Alomà, Martau Pompeu Fabra University,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,Carlos III Health Institute4 aut
7001 a Vilor-Tejedor, Natàliau Center for Genomic Regulation (CRG),Pompeu Fabra University,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Operto, Grégoryu Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,Carlos III Health Institute4 aut
7001 a Falcon, Carlesu Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Grau-Rivera, Oriolu Hospital del Mar Medical Research Institute,Carlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Arenaza-Urquijo, Eider M.u Hospital del Mar Medical Research Institute,Carlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Minguillón, Carolinau Hospital del Mar Medical Research Institute,Carlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Fauria, Karineu Carlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Molinuevo, José Luisu H. Lundbeck A/S,Pasqual Maragall Foundation for Research on Alzheimer4 aut
7001 a Suárez-Calvet, Marcu Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,Carlos III Health Institute4 aut
7001 a Gispert, Juan Domingou Pasqual Maragall Foundation for Research on Alzheimer,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Hospital del Mar Medical Research Institute4 aut
7001 a Cañas, Alba4 aut
7001 a Canals, Lidia4 aut
7001 a Iglesias, Laura4 aut
7001 a Marne, Paula4 aut
7001 a Beteta, Annabella4 aut
7001 a Deulofeu, Carme4 aut
7001 a Emilio, Maria4 aut
7001 a Cumplido, Irene4 aut
7001 a Domínguez, Ruth4 aut
7001 a Fuentes, Sherezade4 aut
7001 a Hernández, Laura4 aut
7001 a Vilanova, Marc4 aut
7001 a Solsona, Lluís4 aut
7001 a Huesa, Gema4 aut
7001 a Huguet, Jordi4 aut
7001 a Menchón, Tania4 aut
7001 a Polo, Albina4 aut
7001 a Pradas, Sandra4 aut
7001 a Sala-Vila, Aleix4 aut
7001 a Soteras, Anna4 aut
7001 a Stankeviciute, Laura4 aut
7001 a Akinci, Müge4 aut
7001 a Palpatzis, Eleni4 aut
7001 a Genius, Patricia4 aut
7001 a Rodríguez, Blanca4 aut
7001 a García, Marina4 aut
7001 a Ortiz-Romero, Paula4 aut
7102 a Hospital del Mar Medical Research Instituteb Carlos III Health Institute4 org
7102 a ALFA Study
7730 t EJNMMI Researchd : Springer Science and Business Media LLCg 13:1q 13:1x 2191-219X
8564 u http://dx.doi.org/10.1186/s13550-023-00967-6x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/ea1185a4-af23-429b-bf82-28e93942b49f
8564 8u https://doi.org/10.1186/s13550-023-00967-6

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