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Sökning: WFRF:(Gil Pedro G) > (2011-2014) > Effectiveness of ar...

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FältnamnIndikatorerMetadata
00004746naa a2200529 4500
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003SwePub
008110415s2011 | |||||||||||000 ||eng|
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009oai:DiVA.org:du-10444
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1516562 URI
0247 a https://doi.org/10.1186/1475-2875-10-642 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1222416752 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-104442 URI
040 a (SwePub)uud (SwePub)kid (SwePub)du
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ngasala, Billy E.4 aut
2451 0a Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania :b an open label prospective study
264 c 2011-03-16
264 1b Springer Science and Business Media LLC,c 2011
338 a print2 rdacarrier
520 a Background: Home-management of malaria (HMM) strategy improves early access of anti-malarial medicines to high-risk groups in remote areas of sub-Saharan Africa. However, limited data are available on the effectiveness of using artemisinin-based combination therapy (ACT) within the HMM strategy. The aim of this study was to assess the effectiveness of artemether-lumefantrine (AL), presently the most favoured ACT in Africa, in under-five children with uncomplicated Plasmodium falciparum malaria in Tanzania, when provided by community health workers (CHWs) and administered unsupervised by parents or guardians at home. Methods: An open label, single arm prospective study was conducted in two rural villages with high malaria transmission in Kibaha District, Tanzania. Children presenting to CHWs with uncomplicated fever and a positive rapid malaria diagnostic test (RDT) were provisionally enrolled and provided AL for unsupervised treatment at home. Patients with microscopy confirmed P. falciparum parasitaemia were definitely enrolled and reviewed weekly by the CHWs during 42 days. Primary outcome measure was PCR corrected parasitological cure rate by day 42, as estimated by Kaplan-Meier survival analysis. This trial is registered with ClinicalTrials.gov, number NCT00454961. Results: A total of 244 febrile children were enrolled between March-August 2007. Two patients were lost to follow up on day 14, and one patient withdrew consent on day 21. Some 141/241 (58.5%) patients had recurrent infection during follow-up, of whom 14 had recrudescence. The PCR corrected cure rate by day 42 was 93.0% (95% CI 88.3%-95.9%). The median lumefantrine concentration was statistically significantly lower in patients with recrudescence (97 ng/mL [IQR 0-234]; n = 10) compared with reinfections (205 ng/mL [114-390]; n = 92), or no parasite reappearance (217 [121-374] ng/mL; n = 70; p <= 0.046). Conclusions: Provision of AL by CHWs for unsupervised malaria treatment at home was highly effective, which provides evidence base for scaling-up implementation of HMM with AL in Tanzania.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
653 a MEDICINE
653 a MEDICIN
653 a Hälsa och välfärd
7001 a Malmberg, Majau Karolinska Institutet4 aut
7001 a Carlsson, Anja M.u Karolinska Institutet4 aut
7001 a Ferreira, Pedro E.u Karolinska Institutet4 aut
7001 a Petzold, Max G.4 aut
7001 a Blessborn, Danielu Högskolan Dalarna,Uppsala universitet,Institutionen för fysikalisk och analytisk kemi,Medicinsk vetenskap4 aut0 (Swepub:du)dbl
7001 a Bergqvist, Yngveu Högskolan Dalarna,Uppsala universitet,Analytisk kemi,Medicinsk vetenskap4 aut0 (Swepub:du)ybq
7001 a Gil, Jose P.u Karolinska Institutet4 aut
7001 a Premji, Zul4 aut
7001 a Mårtensson, Andreas4 aut
7102 a Karolinska Institutetb Institutionen för fysikalisk och analytisk kemi4 org
7730 t Malaria Journald : Springer Science and Business Media LLCg 10, s. 64-q 10<64-x 1475-2875
8564 u https://malariajournal.biomedcentral.com/track/pdf/10.1186/1475-2875-10-64
8564 u https://du.diva-portal.org/smash/get/diva2:542734/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151656
8564 8u https://doi.org/10.1186/1475-2875-10-64
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:122241675
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-10444

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