SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Glover Gary H.)
 

Sökning: WFRF:(Glover Gary H.) > (2018) > Striatal dopamine d...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004851naa a2200529 4500
001oai:DiVA.org:liu-153526
003SwePub
008181220s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1535262 URI
0247 a https://doi.org/10.1038/s41398-018-0316-22 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hamilton, Paulu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)pauha77
2451 0a Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent C-11-raclopride positron emission tomography and functional magnetic resonance imaging investigation
264 c 2018-11-30
264 1b NATURE PUBLISHING GROUP,c 2018
338 a electronic2 rdacarrier
500 a Funding Agencies|Weston Havens Foundation
520 a Major depressive disorder (MDD) is characterized by the altered integration of reward histories and reduced responding of the striatum. We have posited that this reduced striatal activation in MDD is due to tonically decreased stimulation of striatal dopamine synapses which results in decremented propagation of information along the corticostriatal-pallido-thalamic (CSPT) spiral. In the present investigation, we tested predictions of this formulation by conducting concurrent functional magnetic resonance imaging (fMRI) and C-11-raclopride positron emission tomography (PET) in depressed and control (CTL) participants. We scanned 16 depressed and 14 CTL participants with simultaneous fMRI and C-11-raclopride PET. We estimated raclopride binding potential (BPND), voxel-wise, and compared MDD and CTL samples with respect to BPND in the striatum. Using striatal regions that showed significant between-group BPND differences as seeds, we conducted whole-brain functional connectivity analysis using the fMRI data and identified brain regions in each group in which connectivity with striatal seed regions scaled linearly with BPND from these regions. We observed increased BPND in the ventral striatum, bilaterally, and in the right dorsal striatum in the depressed participants. Further, we found that as BPND increased in both the left ventral striatum and right dorsal striatum in MDD, connectivity with the cortical targets of these regions (default-mode network and salience network, respectively) decreased. Deficits in stimulation of striatal dopamine receptors in MDD could account in part for the failure of transfer of information up the CSPT circuit in the pathophysiology of this disorder.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Sacchet, Matthew D.u Stanford Univ, CA 94305 USA4 aut
7001 a Hjornevik, Trineu Oslo Univ Hosp, Norway; Norwegian Med Cyclotron Ctr, Norway; Stanford Univ, CA 94305 USA4 aut
7001 a Chin, Frederick T.u Stanford Univ, CA 94305 USA4 aut
7001 a Shen, Binu Stanford Univ, CA 94305 USA4 aut
7001 a Kämpe, Robinu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)robka95
7001 a Park, Jun Hyungu Stanford Univ, CA 94305 USA4 aut
7001 a Knutson, Brian D.u Stanford Univ, CA USA4 aut
7001 a Williams, Leanne M.u Stanford Univ, CA 94305 USA4 aut
7001 a Borg, Nicholasu Stanford Univ, CA USA4 aut
7001 a Zaharchuk, Gregu Stanford Univ, CA 94305 USA4 aut
7001 a Camacho, M. Catalinau Univ Pittsburgh, PA 15260 USA4 aut
7001 a Mackey, Seanu Stanford Univ, CA 94305 USA4 aut
7001 a Heilig, Markusu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken4 aut0 (Swepub:liu)marhe41
7001 a Drevets, Wayne C.u Janssen Res and Dev LLC, NJ USA4 aut
7001 a Glover, Gary H.u Stanford Univ, CA 94305 USA4 aut
7001 a Gambhir, Sanjiv S.u Stanford Univ, CA 94305 USA4 aut
7001 a Gotlib, Ian H.u Stanford Univ, CA USA4 aut
7102 a Linköpings universitetb Centrum för social och affektiv neurovetenskap4 org
7730 t Translational Psychiatryd : NATURE PUBLISHING GROUPg 8q 8x 2158-3188
8564 u https://liu.diva-portal.org/smash/get/diva2:1273243/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41398-018-0316-2.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153526
8564 8u https://doi.org/10.1038/s41398-018-0316-2

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy