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An oomycete NLP cyt...
An oomycete NLP cytolysin forms transient small pores in lipid membranes
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- Pirc, Katja (author)
- Kemijski Institut,National Institute of Chemistry Slovenia
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- Clifton, Luke A. (author)
- STFC Rutherford Appleton Laboratory
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- Yilmaz, Neval (author)
- RIKEN
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- Saltalamacchia, Andrea (author)
- Scuola Internazionale Superiore di Studi Avanzati
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- Mally, Mojca (author)
- Univerza V Ljubljani,University of Ljubljana
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- Snoj, Tina (author)
- Kemijski Institut,National Institute of Chemistry Slovenia
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- Žnidaršič, Nada (author)
- Univerza V Ljubljani,University of Ljubljana
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- Srnko, Marija (author)
- Kemijski Institut,National Institute of Chemistry Slovenia
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- Borišek, Jure (author)
- Kemijski Institut,National Institute of Chemistry Slovenia
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- Parkkila, Petteri, 1990 (author)
- Helsingin Yliopisto,University of Helsinki,Chalmers tekniska högskola,Chalmers University of Technology
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- Albert, Isabell (author)
- Friedrich-Alexander-Universität Erlangen Nurnberg (FAU),Eberhard Karls Universität Tübingen,Eberhard Karls University of Tübingen
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- Podobnik, Marjetka (author)
- Kemijski Institut,National Institute of Chemistry Slovenia
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- Numata, Keiji (author)
- RIKEN
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- Nürnberger, Thorsten (author)
- University of Johannesburg,Eberhard Karls Universität Tübingen,Eberhard Karls University of Tübingen
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- Viitala, Tapani (author)
- Helsingin Yliopisto,University of Helsinki
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- Derganc, Jure (author)
- Univerza V Ljubljani,University of Ljubljana
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- Magistrato, Alessandra (author)
- Scuola Internazionale Superiore di Studi Avanzati
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- Lakey, Jeremy H. (author)
- University of Newcastle upon Tyne
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- Anderluh, Gregor (author)
- Kemijski Institut,National Institute of Chemistry Slovenia
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2022
- 2022
- English.
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In: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 8:10, s. eabj9406-
- Related links:
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.1...
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Abstract
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- Microbial plant pathogens secrete a range of effector proteins that damage host plants and consequently constrain global food production. Necrosis and ethylene-inducing peptide 1-like proteins (NLPs) are produced by numerous phytopathogenic microbes that cause important crop diseases. Many NLPs are cytolytic, causing cell death and tissue necrosis by disrupting the plant plasma membrane. Here, we reveal the unique molecular mechanism underlying the membrane damage induced by the cytotoxic model NLP. This membrane disruption is a multistep process that includes electrostatic-driven, plant-specific lipid recognition, shallow membrane binding, protein aggregation, and transient pore formation. The NLP-induced damage is not caused by membrane reorganization or large-scale defects but by small membrane ruptures. This distinct mechanism of lipid membrane disruption is highly adapted to effectively damage plant cells.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Växtbioteknologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Plant Biotechnology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Pirc, Katja
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Clifton, Luke A.
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Yilmaz, Neval
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Saltalamacchia, ...
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Mally, Mojca
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Snoj, Tina
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show more...
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Žnidaršič, Nada
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Srnko, Marija
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Borišek, Jure
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Parkkila, Petter ...
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Albert, Isabell
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Podobnik, Marjet ...
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Numata, Keiji
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Nürnberger, Thor ...
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Viitala, Tapani
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Derganc, Jure
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Magistrato, Ales ...
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Lakey, Jeremy H.
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Anderluh, Gregor
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Plant Biotechnol ...
- Articles in the publication
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Science advances
- By the university
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Chalmers University of Technology