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  • Fehlmann, Tobias (author)

Common diseases alter the physiological age-related blood microRNA profile

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-11-24
  • Springer Science and Business Media LLC,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-189753
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-189753URI
  • https://doi.org/10.1038/s41467-020-19665-1DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lehallier, Benoit (author)
  • Schaum, Nicholas (author)
  • Hahn, Oliver (author)
  • Kahraman, Mustafa (author)
  • Li, Yongping (author)
  • Grammes, Nadja (author)
  • Geffers, Lars (author)
  • Backes, Christina (author)
  • Balling, Rudi (author)
  • Kern, Fabian (author)
  • Krüger, Rejko (author)
  • Lammert, Frank (author)
  • Ludwig, Nicole (author)
  • Meder, Benjamin (author)
  • Fromm, BastianStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)bafr4281 (author)
  • Maetzler, Walter (author)
  • Berg, Daniela (author)
  • Brockmann, Kathrin (author)
  • Deuschle, Christian (author)
  • von Thaler, Anna-Katharina (author)
  • Eschweiler, Gerhard W. (author)
  • Milman, Sofiya (author)
  • Barziliai, Nir (author)
  • Reichert, Matthias (author)
  • Wyss-Coray, Tony (author)
  • Meese, Eckart (author)
  • Keller, Andreas (author)
  • Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC11:12041-1723

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