Sökning: WFRF:(Herter Eva K) > WAKMAR2, a Long Non...
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003 | SwePub | |
008 | 190625s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:140987850 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3864432 URI |
024 | 7 | a https://doi.org/10.1016/j.jid.2018.11.0332 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1409878502 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Herter, Eva K.u Karolinska Inst, Dermatol & Venereol Sect, Dept Med Solna, SE-17176 Stockholm, Sweden4 aut |
245 | 1 0 | a WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines |
264 | 1 | b ELSEVIER SCIENCE INC,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Chronic wounds represent a major and growing health and economic burden worldwide. A better understanding of molecular mechanisms of normal as well as impaired wound healing is needed to develop effective treatment. Herein we studied the potential role of long noncoding RNA LOC100130476 in skin wound repair. LOC100130476 is an RNA polymerase IIeencoded polyadenylated transcript present in both cytoplasm and nucleus. We found that its expression was lower in wound-edge keratinocytes of human chronic wounds compared to normal wounds of healthy donors and intact skin. In cultured keratinocytes, LOC100130476 expression was induced by TGF-beta signaling. By reducing LOC100130476 expression with antisense oligos or activating its transcription with CRISPR/Cas9 Synergistic Activation Mediator system, we showed that LOC100130476 restricted the production of inflammatory chemokines by keratinocytes, while enhancing cell migration. In line with this, knockdown of LOC100130476 impaired re-epithelization of human ex vivo wounds. Based on these results, we named LOC100130476 wound and keratinocyte migration-associated long noncoding RNA 2 (WAKMAR2). Moreover, we identified a molecular network that may mediate the biological function of WAKMAR2 in keratinocytes using microarray. In summary, our data suggest that WAKMAR2 is an important regulator of skin wound healing and its deficiency may contribute to the pathogenesis of chronic wounds. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng |
700 | 1 | a Li, Dongqingu Karolinska Institutet4 aut |
700 | 1 | a Toma, Maria A.u Karolinska Institutet4 aut |
700 | 1 | a Vij, Manikau Karolinska Inst, Dermatol & Venereol Sect, Dept Med Solna, SE-17176 Stockholm, Sweden4 aut |
700 | 1 | a Li, Xiu Karolinska Inst, Dermatol & Venereol Sect, Dept Med Solna, SE-17176 Stockholm, Sweden4 aut |
700 | 1 | a Visscher, Daniu Karolinska Inst, Dermatol & Venereol Sect, Dept Med Solna, SE-17176 Stockholm, Sweden4 aut |
700 | 1 | a Wang, Aoxueu Dalian Med Univ, Dept Dermatol, Hosp 2, Dalian, Peoples R China4 aut |
700 | 1 | a Chu, Tongbinu Dalian Med Univ, Hosp 2, Dept Wound Regenerat, Dalian, Peoples R China4 aut |
700 | 1 | a Sommar, Pehru Karolinska Institutet4 aut |
700 | 1 | a Blomqvist, Lennartu Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden4 aut |
700 | 1 | a Berglund, David,d 1984-u Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)davbe892 |
700 | 1 | a Stahle, Monau Karolinska Institutet4 aut |
700 | 1 | a Wikstrom, Jakob D.u Karolinska Institutet4 aut |
700 | 1 | a Landen, Ning Xuu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Karolinska Inst, Dermatol & Venereol Sect, Dept Med Solna, SE-17176 Stockholm, Sweden4 org |
773 | 0 | t Journal of Investigative Dermatologyd : ELSEVIER SCIENCE INCg 139:6, s. 1373-1384q 139:6<1373-1384x 0022-202Xx 1523-1747 |
856 | 4 | u https://doi.org/10.1016/j.jid.2018.11.033y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1330456/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.jidonline.org/article/S0022202X18013015/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-386443 |
856 | 4 8 | u https://doi.org/10.1016/j.jid.2018.11.033 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140987850 |
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