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FältnamnIndikatorerMetadata
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0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1095882 URI
0247 a https://doi.org/10.1016/j.vaccine.2023.10.0282 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2173392 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1544064162 URI
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0247 a https://gup.ub.gu.se/publication/3301192 URI
040 a (SwePub)orud (SwePub)umud (SwePub)kid (SwePub)liud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Akhtar, Zubairu Biosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Programme on Emerging Infections, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh4 aut
2451 0a Optimal timing of influenza vaccination among patients with acute myocardial infarction - Findings from the IAMI trial
264 1b Elsevier,c 2023
338 a print2 rdacarrier
500 a This work was funded by a grant from the Swedish Heart-Lung Foundation (project number 20150284) , the Danish Heart Foundation (grant number 16-R107-A6596-22958) , ALF Grants, and Nyckelfonden, Region Örebro, Sweden and by an unrestricted grant from Sanofi Pasteur, Lyon, France, who also provided the study vaccine.
500 a Funding Agencies|Swedish Heart-Lung Foundation [20150284]; Danish Heart Foundation [16-R107-A6596-22958]; ALF Grants; Nyckelfonden; Region Orebro,Sweden; Sanofi Pasteur, Lyon, France
520 a Influenza vaccination reduces the risk of adverse cardiovascular events. The IAMI trial randomly assigned 2571 patients with acute myocardial infarction (AMI) to receive influenza vaccine or saline placebo during their index hospital admission. It was conducted at 30 centers in 8 countries from October 1, 2016 to March 1, 2020. In this post-hoc exploratory sub-study, we compare the trial outcomes in patients receiving early season vaccination (n = 1188) and late season vaccination (n = 1344). The primary endpoint was the composite of all-cause death, myocardial infarction (MI), or stent thrombosis at 12 months. The cumulative incidence of the primary and key secondary endpoints by randomized treatment and early or late vaccination was estimated using the Kaplan-Meier method. In the early vaccinated group, the primary composite endpoint occurred in 36 participants (6.0%) assigned to influenza vaccine and 49 (8.4%) assigned to placebo (HR 0.69; 95% CI 0.45 to 1.07), compared to 31 participants (4.7%) assigned to influenza vaccine and 42 (6.2%) assigned to placebo (HR 0.74; 95% CI 0.47 to 1.18) in the late vaccinated group (P = 0.848 for interaction on HR scale at 1 year). We observed similar estimates for the key secondary endpoints of all-cause death and CV death. There was no statistically significant difference in vaccine effectiveness against adverse cardiovascular events by timing of vaccination. The effect of vaccination on all-cause death at one year was more pronounced in the group receiving early vaccination (HR 0.50; 95% CI, 0.29 to 0.86) compared late vaccination group (HR 0.75; 35% CI, 0.40 to 1.40) but there was no statistically significant difference between these groups (Interaction P = 0.335). In conclusion, there is insufficient evidence from the trial to establish whether there is a difference in efficacy between early and late vaccination but regardless of vaccination timing we strongly recommend influenza vaccination in all patients with cardiovascular diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
653 a Influenza vaccination
653 a Myocardial infarction
653 a Optimal timing
653 a Percutaneous coronary intervention
653 a Vaccine effectiveness
7001 a Götberg, Matthiasu Department of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden4 aut
7001 a Erlinge, Davidu Department of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden4 aut
7001 a Christiansen, Evald H.u Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark4 aut
7001 a Oldroyd, Keith G.u Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom,Univ Glasgow, Scotland4 aut
7001 a Motovska, Zuzanau Cardiocenter, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic,Charles Univ Prague, Czech Republic; Univ Hosp Kralovske Vinohrady, Czech Republic4 aut
7001 a Erglis, Andrejsu Pauls Stradins Clinical University Hospital, University of Latvia, Riga, Latvia,Univ Latvia, Latvia4 aut
7001 a Hlinomaz, Otau International Clinical Research Center, St. Anne University Hospital and Masaryk University, Brno, Czech Republic,St Anne Univ Hosp, Czech Republic; Masaryk Univ, Czech Republic4 aut
7001 a Jakobsen, Larsu Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark4 aut
7001 a Engstrøm, Thomasu Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark4 aut
7001 a Jensen, Lisette O.u Department of Cardiology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark4 aut
7001 a Fallesen, Christian O.u Department of Cardiology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark4 aut
7001 a Jensen, Svend Eu Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Aalborg Univ, Denmark4 aut
7001 a Angerås, Oskar,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xangos
7001 a Calais, Fredrik,d 1971-u Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden,Orebro Univ, Sweden4 aut0 (Swepub:oru)fcs
7001 a Kåregren, Amrau Västmanlands sjukhus Västerås, Västerås, Sweden4 aut
7001 a Lauermann, Jorgu Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Reg Jonkoping Cty, Sweden4 aut0 (Swepub:liu)n/a
7001 a Mokhtari, Arashu Department of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden4 aut
7001 a Nilsson, Johanu Umeå universitet,Kardiologi,Umea Univ, Sweden4 aut0 (Swepub:umu)joni0050
7001 a Persson, Jonasu Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Islam, Abu K. M. M.u National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh4 aut
7001 a Rahman, Afzaluru National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh4 aut
7001 a Malik, Fazilau National Heart Foundation Hospital & Research Institute, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh4 aut
7001 a Choudhury, Sohelu National Heart Foundation Hospital & Research Institute, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh4 aut
7001 a Collier, Timothyu Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom,London Sch Hyg & Trop Med, England4 aut
7001 a Pocock, Stuart J.u Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom,London Sch Hyg & Trop Med, England4 aut
7001 a Pernow, Johnu Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden4 aut
7001 a MacIntyre, Chandini R.u Biosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Cardiology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden,Univ New South Wales, Australia; Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden4 aut
7001 a Fröbert, Ole,d 1964-u Örebro universitet, Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden; College of Public Service & Community Solutions, Arizona State University, Tempe, AZ, USA; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Arhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden; College of Public Service & Community Solutions, Arizona State University, AZ, Tempe, United States; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Arhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark,Orebro Univ, Sweden; Arizona State Univ, AZ USA; Aarhus Univ, Denmark; Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark4 aut0 (Swepub:oru)oft
7102 a Biosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Programme on Emerging Infections, Infectious Diseases Division, icddr,b, Dhaka, Bangladeshb Department of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden4 org
7730 t Vaccined : Elsevierg 41:48, s. 7159-7165q 41:48<7159-7165x 0264-410Xx 1873-2518
8564 u https://doi.org/10.1016/j.vaccine.2023.10.028y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1816752/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109588
8564 8u https://doi.org/10.1016/j.vaccine.2023.10.028
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217339
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:154406416
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200058
8564 8u https://gup.ub.gu.se/publication/330119

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