SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Horn Biljana)
 

Sökning: WFRF:(Horn Biljana) > (2013) > Allogeneic hematopo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004491naa a2200637 4500
001oai:gup.ub.gu.se/177163
003SwePub
008240528s2013 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:126647278
0247 a https://gup.ub.gu.se/publication/1771632 URI
0247 a https://doi.org/10.1200/JCO.2012.45.97192 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1266472782 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ayas, Mouhab4 aut
2451 0a Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia.
264 1c 2013
520 a PURPOSE Allogeneic hematopoietic cell transplantation (HCT) can cure bone marrow failure in patients with Fanconi anemia (FA). Data on outcomes in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome (MDS), or acute leukemia have not been separately analyzed. PATIENTS AND METHODS We analyzed data on 113 patients with FA with cytogenetic abnormalities (n = 54), MDS (n = 45), or acute leukemia (n = 14) who were reported to the Center for International Blood and Marrow Transplant Research from 1985 to 2007. Results Neutrophil recovery occurred in 78% and 85% of patients at days 28 and 100, respectively. Day 100 cumulative incidences of acute graft-versus-host disease grades B to D and C to D were 26% (95% CI, 19% to 35%) and 12% (95% CI, 7% to 19%), respectively. Survival probabilities at 1, 3, and 5 years were 64% (95% CI, 55% to 73%), 58% (95% CI, 48% to 67%), and 55% (95% CI, 45% to 64%), respectively. In univariate analysis, younger age was associated with superior 5-year survival (≤ v > 14 years: 69% [95% CI, 57% to 80%] v 39% [95% CI, 26% to 53%], respectively; P = .001). In transplantations from HLA-matched related donors (n = 82), younger patients (≤ v > 14 years: 78% [95% CI, 64% to 90%] v 34% [95% CI, 20% to 50%], respectively; P < .001) and patients with cytogenetic abnormalities only versus MDS/acute leukemia (67% [95% CI, 52% to 81%] v 43% [95% CI, 27% to 59%], respectively; P = .03) had superior 5-year survival. CONCLUSION Our analysis indicates that long-term survival for patients with FA with cytogenetic abnormalities, MDS, or acute leukemia is achievable. Younger patients and recipients of HLA-matched related donor transplantations who have cytogenetic abnormalities only have the best survival.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Saber, Wael4 aut
7001 a Davies, Stella M4 aut
7001 a Harris, Richard E4 aut
7001 a Hale, Gregory A4 aut
7001 a Socie, Gerard4 aut
7001 a Lerademacher, Jennifer4 aut
7001 a Thakar, Monica4 aut
7001 a Deeg, H Joachim J4 aut
7001 a Al-Seraihy, Amal4 aut
7001 a Battiwalla, Minoo4 aut
7001 a Camitta, Bruce M4 aut
7001 a Olsson, Richardu Karolinska Institutet4 aut
7001 a Bajwa, Rajinder S4 aut
7001 a Bonfim, Carmem M4 aut
7001 a Pasquini, Ricardo4 aut
7001 a Macmillan, Margaret L4 aut
7001 a George, Biju4 aut
7001 a Copelan, Edward A4 aut
7001 a Wirk, Baldeep4 aut
7001 a Al Jefri, Abdullah4 aut
7001 a Fasth, Anders,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xfasan
7001 a Guinan, Eva C4 aut
7001 a Horn, Biljana N4 aut
7001 a Lewis, Victor A4 aut
7001 a Slavin, Shimon4 aut
7001 a Stepensky, Polina4 aut
7001 a Bierings, Marc4 aut
7001 a Gale, Robert Peter4 aut
7102 a Karolinska Institutetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org
7730 t Journal of Clinical Oncologyg 31:13, s. 1669-76q 31:13<1669-76x 0732-183Xx 1527-7755
8564 8u https://gup.ub.gu.se/publication/177163
8564 8u https://doi.org/10.1200/JCO.2012.45.9719
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126647278

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy