WFRF:(Hsu Tsui Ling)
Sökning: WFRF:(Hsu Tsui Ling) > (2013) > Immunization of fuc...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04188naa a2200625 4500 | |
| 001 | oai:DiVA.org:kth-211522 | |
| 003 | SwePub | |
| 008 | 170806s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2115222 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.13124571102 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Liao, Shih-Fen4 aut |
| 245 | 1 0 | a Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes. |
| 264 | c 2013-08 | |
| 264 | 1 | b Proceedings of the National Academy of Sciences,c 2013 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20170809 | |
| 520 | a Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides has been used as antitumor supplement, but the mechanism of immune response has rarely been studied. Here, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi polysaccharide fraction (designated as FMS) induce antibodies against murine Lewis lung carcinoma cells, with increased antibody-mediated cytotoxicity and reduced production of tumor-associated inflammatory mediators (in particular, monocyte chemoattractant protein-1). The mice showed a significant increase in the peritoneal B1 B-cell population, suggesting FMS-mediated anti-glycan IgM production. Furthermore, the glycan microarray analysis of FMS-induced antisera displayed a high specificity toward tumor-associated glycans, with the antigenic structure located in the nonreducing termini (i.e., Fucα1-2Galβ1-3GalNAc-R, where Gal, GalNAc, and R represent, respectively, D-galactose, D-N-acetyl galactosamine, and reducing end), typically found in Globo H and related tumor antigens. The composition of FMS contains mainly the backbone of 1,4-mannan and 1,6-α-galactan and through the Fucα1-2Gal, Fucα1-3/4Man, Fucα1-4Xyl, and Fucα1-2Fuc linkages (where Man and Xyl represent d-mannose and d-xylose, respectively), underlying the molecular basis of the FMS-induced IgM antibodies against tumor-specific glycans. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a anti-Globo H antibody | |
| 653 | a antitumor activity | |
| 653 | a mushroom polysaccharide | |
| 700 | 1 | a Liang, Chi-Hui4 aut |
| 700 | 1 | a Ho, Ming-Yi4 aut |
| 700 | 1 | a Hsu, Tsui-Ling4 aut |
| 700 | 1 | a Tsai, Tsung-I4 aut |
| 700 | 1 | a Hsieh, Yves S-Yu Academia Sinica, Taiwan4 aut0 (Swepub:kth)u1a596wi |
| 700 | 1 | a Tsai, Chih-Ming4 aut |
| 700 | 1 | a Li, Shiou-Ting4 aut |
| 700 | 1 | a Cheng, Yang-Yu4 aut |
| 700 | 1 | a Tsao, Shu-Ming4 aut |
| 700 | 1 | a Lin, Tung-Yi4 aut |
| 700 | 1 | a Lin, Zong-Yan4 aut |
| 700 | 1 | a Yang, Wen-Bin4 aut |
| 700 | 1 | a Ren, Chien-Tai4 aut |
| 700 | 1 | a Lin, Kuo-I4 aut |
| 700 | 1 | a Khoo, Kay-Hooi4 aut |
| 700 | 1 | a Lin, Chun-Hung4 aut |
| 700 | 1 | a Hsu, Hsien-Yeh4 aut |
| 700 | 1 | a Wu, Chung-Yi4 aut |
| 700 | 1 | a Wong, Chi-Huey4 aut |
| 710 | 2 | a Academia Sinica, Taiwan4 org |
| 773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 110:34, s. 13809-13814q 110:34<13809-13814x 0027-8424x 1091-6490 |
| 856 | 4 | u https://www.pnas.org/content/pnas/110/34/13809.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-211522 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.1312457110 |
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