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FältnamnIndikatorerMetadata
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001oai:DiVA.org:oru-96668
003SwePub
008220125s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-469771
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0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-966682 URI
0247 a https://doi.org/10.1016/j.clnu.2021.12.0312 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4697712 URI
0247 a https://lup.lub.lu.se/record/6bf86c9b-94ac-4a6f-8b58-105864cf0ab42 URI
040 a (SwePub)orud (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gürdeniz, Gözdeu Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmark,Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark.;Univ Copenhagen, Dept Food Sci, Frederiksberg, Denmark4 aut
2451 0a Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids
264 1b Elsevier,c 2021
338 a print2 rdacarrier
520 a BACKGROUND & AIMS: Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers.METHODS: During 18-24 weeks of intervention, 200 participants with metabolic syndrome were advised at six centres to eat either HND (e.g. whole-grain products, berries, rapeseed oil, fish and low-fat dairy) or CD while being weight stable. Of these 166/159 completers delivered blood/urine samples. Metabolic profiles of fasting plasma and 24 h pooled urine were analysed to identify characteristic diet-related patterns. Principal components analysis (PCA) scores (i.e. PC1 and PC2 scores) were used to test their combined effect on blood glucose response (primary endpoint), serum lipoproteins, triglycerides, and inflammatory markers.RESULTS: The profiles distinguished HND and CD with AUC of 0.96 ± 0.03 and 0.93 ± 0.02 for plasma and urine, respectively, with limited heterogeneity between centers, reflecting markers of key foods. Markers of fish, whole grain and polyunsaturated lipids characterized HND, while CD was reflected by lipids containing palmitoleic acid. The PC1 scores of plasma metabolites characterizing the intervention is associated with HDL (β = 0.05; 95% CI: 0.02, 0.08; P = 0.001) and triglycerides (β = -0.06; 95% CI: -0.09, -0.03; P < 0.001). PC2 scores were related with glucose metabolism (2 h Glucose, β = 0.1; 95% CI: 0.05, 0.15; P < 0.001), LDL (β = 0.06; 95% CI: 0.01, 0.1; P = 0.02) and triglycerides (β = 0.11; 95% CI: 0.06, 0.15; P < 0.001). For urine, the scores were related with LDL cholesterol.CONCLUSIONS: Plasma and urine metabolite profiles from SYSDIET reflected good compliance with dietary recommendations across the region. The scores of metabolites characterizing the diets associated with outcomes related with cardio-metabolic risk. Our analysis therefore offers a novel way to approach a per protocol analysis with a balanced compliance assessment in larger multicentre dietary trials. The study was registered at clinicaltrials.gov with NCT00992641.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a Glucose and lipid metabolism
653 a Healthy Nordic diet
653 a LC–MS metabolomics
653 a Plasma metabolite scores
653 a Randomized controlled trial
653 a Glucose and lipid metabolism
653 a Healthy Nordic diet
653 a LC–MS metabolomics
653 a Plasma metabolite scores
653 a Randomized controlled trial
7001 a Uusitupa, Mattiu Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland4 aut
7001 a Hermansen, Kjeldu Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark4 aut
7001 a Savolainen, Markku J.u Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland,Univ Oulu, Inst Clin Med, Dept Internal Med, Oulu, Finland4 aut
7001 a Schwab, Ursulau Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio, Finland4 aut
7001 a Kolehmainen, Marjukkau Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland4 aut
7001 a Brader, Leau Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark4 aut
7001 a Cloetens, Lieselotteu Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)tbio-lce
7001 a Herzig, Karl-Heinzu Institute of Biomedicine and Biocenter of Oulu, University of Oulu, Finland; Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland,Univ Oulu, Inst Biomed, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland4 aut
7001 a Hukkanen, Janneu Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland,Univ Oulu, Inst Clin Med, Dept Internal Med, Oulu, Finland4 aut
7001 a Rosqvist, Fredrik,d 1985-u Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap4 aut0 (Swepub:uu)frero353
7001 a Ulven, Stine Marieu Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway,Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway4 aut
7001 a Gunnarsdóttir, Ingibjörgu Unit for Nutrition Research, Faculty of Food Science and Nutrition, University of Iceland, Reykjavík, Iceland; Unit for Nutrition Research, Landspitali National University Hospital, Reykjavik, Iceland,Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Natl Univ Hosp, Unit Nutr Res, Reykjavik, Iceland4 aut
7001 a Thorsdottir, Ingau Unit for Nutrition Research, Faculty of Food Science and Nutrition, University of Iceland, Reykjavík, Iceland; Unit for Nutrition Research, Landspitali National University Hospital, Reykjavik, Iceland,Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Natl Univ Hosp, Unit Nutr Res, Reykjavik, Iceland4 aut
7001 a Oresic, Matej,d 1967-u Turku Center for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Turku, Turku Ctr Biotechnol, Turku, Finland.;Abo Akad Univ, Turku, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland4 aut0 (Swepub:oru)moc
7001 a Poutanen, Kaisa S.u Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland4 aut
7001 a Risérus, Ulf,d 1967-u Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap4 aut0 (Swepub:uu)ulfriser
7001 a Åkesson, Björnu Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital4 aut0 (Swepub:lu)kc-bak
7001 a Dragsted, Lars Oveu Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg,Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark4 aut
7102 a Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg, Denmarkb Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark.;Univ Copenhagen, Dept Food Sci, Frederiksberg, Denmark4 org
7730 t Clinical Nutritiond : Elsevierg 41:2, s. 441-451q 41:2<441-451x 0261-5614x 1532-1983
8564 u https://doi.org/10.1016/j.clnu.2021.12.031y Fulltext
8564 u http://www.clinicalnutritionjournal.com/article/S0261561421005963/pdf
8564 u https://uu.diva-portal.org/smash/get/diva2:1644714/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1016/j.clnu.2021.12.031x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-96668
8564 8u https://doi.org/10.1016/j.clnu.2021.12.031
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469771
8564 8u https://lup.lub.lu.se/record/6bf86c9b-94ac-4a6f-8b58-105864cf0ab4

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