Sökning: WFRF:(Iversen Astrid K. N.) > Elevated genetic ri...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03660naa a2200625 4500 | |
001 | oai:gup.ub.gu.se/335282 | |
003 | SwePub | |
008 | 240910s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3352822 URI |
024 | 7 | a https://doi.org/10.1038/s41586-023-06618-z2 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Barrie, William4 aut |
245 | 1 0 | a Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations |
264 | 1 | c 2024 |
520 | a Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment. Analysis of a large ancient genome dataset shows that genetic risk for multiple sclerosis rose in steppe pastoralists, providing insight into how genetic ancestry from the Neolithic and Bronze Age has shaped modern immune responses. | |
650 | 7 | a HUMANIORAx Historia och arkeologi0 (SwePub)6012 hsv//swe |
650 | 7 | a HUMANITIESx History and Archaeology0 (SwePub)6012 hsv//eng |
700 | 1 | a Yang, Yaoling4 aut |
700 | 1 | a Irving-Pease, Evan K.4 aut |
700 | 1 | a Attfield, Kathrine E.4 aut |
700 | 1 | a Scorrano, Gabriele4 aut |
700 | 1 | a Jensen, Lise Torp4 aut |
700 | 1 | a Armen, Angelos P.4 aut |
700 | 1 | a Dimopoulos, Evangelos Antonios4 aut |
700 | 1 | a Stern, Aaron4 aut |
700 | 1 | a Refoyo-Martinez, Alba4 aut |
700 | 1 | a Pearson, Alice4 aut |
700 | 1 | a Ramsoe, Abigail4 aut |
700 | 1 | a Gaunitz, Charleen4 aut |
700 | 1 | a Demeter, Fabrice4 aut |
700 | 1 | a Jorkov, Marie Louise S.4 aut |
700 | 1 | a Moller, Stig Bermann4 aut |
700 | 1 | a Springborg, Bente4 aut |
700 | 1 | a Klassen, Lutz4 aut |
700 | 1 | a Hyldgard, Inger Marie4 aut |
700 | 1 | a Wickmann, Niels4 aut |
700 | 1 | a Vinner, Lasse4 aut |
700 | 1 | a Korneliussen, Thorfinn Sand4 aut |
700 | 1 | a Allentoft, Morten E.4 aut |
700 | 1 | a Sikora, Martin4 aut |
700 | 1 | a Kristiansen, Kristian,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies4 aut0 (Swepub:gu)xkrikr |
700 | 1 | a Rodriguez, Santiago4 aut |
700 | 1 | a Nielsen, Rasmus4 aut |
700 | 1 | a Iversen, Astrid K. N.4 aut |
700 | 1 | a Lawson, Daniel J.4 aut |
700 | 1 | a Fugger, Lars4 aut |
700 | 1 | a Willerslev, Eske4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för historiska studier4 org |
773 | 0 | t NATUREg 625:7994q 625:7994x 0028-0836x 1476-4687 |
856 | 4 8 | u https://gup.ub.gu.se/publication/335282 |
856 | 4 8 | u https://doi.org/10.1038/s41586-023-06618-z |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy