Host tissue reactions of non-demineralized autogenic and xenogenic dentin blocks implanted in a non-osteogenic environment. An experimental study in rabbits.

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Fältnamn	Indikatorer	Metadata
000		03423naa a2200349 4500
001		oai:gup.ub.gu.se/189052
003		SwePub
008		240528s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/1890522 URI
024	7	a https://doi.org/10.1111/edt.120662 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Al-Asfour, Adel4 aut
245	1 0	a Host tissue reactions of non-demineralized autogenic and xenogenic dentin blocks implanted in a non-osteogenic environment. An experimental study in rabbits.
264		c 2013-09-01
264	1	b Wiley,c 2014
520		a Dentoalveolar ankylosis with osseous replacement is often seen after replantation of avulsed teeth, and this process may be used for preservation of alveolar crests after trauma. Its exact mechanisms with regard to osteoinductive properties are not yet fully understood and need to be systematically investigated. Dentin can possibly act as a slow-releasing carrier of bone morphogenic proteins (BMP), and this property of dentin has been proposed to be used as an alternative or supplement to bone grafting in the maxillofacial region. We aimed to initially asses host tissue reactions to dentin by implanting dentin blocks of autogenic and xenogenic human origin in rabbit connective tissue of the abdominal wall and femoral muscle. Animals were sacrificed after a period of 3months, and histological processing, sectioning and examinations were carried out. Bone formation, cell counts and thickness of capsule surrounding the grafts were evaluated. Only minor signs of heterotopic bone formation were seen. There were no significant differences between autografts and xenografts or grafts implanted in connective tissue or muscle with regards to tissue reactions except for a significant difference (P=0.018) in findings of more local inflammatory cells in relation to grafts placed in connective tissue in the autograft group. We conclude that during the time frame of this study, non-demineralized dentin, whether autogenous or xenogenic did not have the potential to induce bone formation when implanted in non-osteogenic areas such as the abdominal wall and abdominal muscle of rabbits.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng
653		a tissue reaction; dentin; bone; osteoinduction; new bone formation
700	1	a Farzad, Payam,d 19734 aut
700	1	a Andersson, Lars4 aut
700	1	a Joseph, Bobby4 aut
700	1	a Dahlin, Christer,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials4 aut0 (Swepub:gu)xdachr
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap4 org
773	0	t Dental traumatology : official publication of International Association for Dental Traumatologyd : Wileyg 30:3, s. 198-203q 30:3<198-203x 1600-9657
773	0	t Dental Traumatologyd : Wileyg 30:3, s. 198-203q 30:3<198-203x 1600-4469
856	4 8	u https://gup.ub.gu.se/publication/189052
856	4 8	u https://doi.org/10.1111/edt.12066

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Av författaren/redakt...: Al-Asfour, Adel; Farzad, Payam, 1 ...; Andersson, Lars; Joseph, Bobby; Dahlin, Christer ...

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