Sökning: WFRF:(Karlsson Mattias) > (2005-2009) > Variants of the int...
Fältnamn | Indikatorer | Metadata |
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000 | 07003naa a2200661 4500 | |
001 | oai:DiVA.org:uu-129068 | |
003 | SwePub | |
008 | 100805s2009 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:5df08013-6bae-4dc7-9f7b-57a1b7ee7191 | |
009 | oai:research.chalmers.se:c3bcc2c9-d6df-490a-a18b-9fb76b0b5839 | |
009 | oai:gup.ub.gu.se/93710 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1290682 URI |
024 | 7 | a https://doi.org/10.1038/ijo.2009.472 DOI |
024 | 7 | a https://lup.lub.lu.se/record/14260052 URI |
024 | 7 | a https://research.chalmers.se/publication/937102 URI |
024 | 7 | a https://gup.ub.gu.se/publication/937102 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)cthd (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andersson, Niklas,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xandni |
245 | 1 0 | a Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men |
264 | c 2009-03-17 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
338 | a print2 rdacarrier | |
520 | a Context: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. Objective: To systematically investigate our hypotheses that single- nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. Subjects: The Gothenburg osteoporosis and obesity determinants (GOOD) study is a population-based cross-sectional study of 18-20 year-old men (n = 1068), from Gothenburg, Sweden. Major findings were confirmed in elderly men (n = 3014) from the Swedish part of the osteoporotic fractures in men (MrOS) multicenter population-based study. Main Outcome Measure: The genotype distributions and their association with body fat mass in different compartments, measured with dual-energy X-ray absorptiometry (DXA). Results: Out of 15 investigated SNPs in the IL-1 receptor antagonist (IL1RN) gene, a recently identified 30 untranslated region C4T (rs4252041, minor allele frequency 4%) SNP was associated with the primary outcome total fat mass (P = 0.003) and regional fat masses, but not with lean body mass or serum IL-1 receptor 1 (IL1RN) levels. This SNP was also associated with body fat when correcting the earlier reported IL1RN_2018 T4C (rs419598) SNP (in linkage disequilibrium with a well-studied variable number tandem repeat of 86 bp). The association between rs4252041 SNP and body fat was confirmed in the older MrOS population (P = 0.03). The rs4252041 SNP was part of three haplotypes consisting of five adjacent SNPs that were identified by a sliding window approach. These haplotypes had a highly significant global association with total body fat (P < 0.001). None of the other investigated members of the IL-1 gene family displayed any SNPs that have not been described previously to be significantly associated with body fat. Conclusions: The IL1RN gene, shown to enhance obesity by suppressing IL-1 effects in experimental animals, have no previously described gene polymorphisms and haplotypes that are associated with fat, but not lean mass in two populations of men. International Journal of Obesity (2009) 33, 525-533; doi: 10.1038/ijo.2009.47; published online 17 March 2009 | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a anakinra | |
653 | a single-nucleotide polymorphism | |
653 | a dual-energy X-ray absorptiometry | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a dual-energy X-ray | |
653 | a anakinra | |
653 | a single-nucleotide polymorphism | |
653 | a absorptiometry | |
700 | 1 | a Strandberg, Louise,d 1981u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xstlou |
700 | 1 | a Nilsson, Staffan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics4 aut0 (Swepub:gu)xnista |
700 | 1 | a Ljunggren, Ou Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University4 aut0 (Swepub:uu)osteljun |
700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skånes universitetssjukhus (SUS),Skåne University Hospital4 aut0 (Swepub:lu)orto-mka |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xlomat |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo |
700 | 1 | a Grahnemo, Louiseu Göteborgs universitet,University of Gothenburg4 aut |
700 | 1 | a Karlsson, K4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org |
773 | 0 | t International Journal of Obesityd : Springer Science and Business Media LLCg 33:5, s. 525-533q 33:5<525-533x 0307-0565x 1476-5497 |
856 | 4 | u http://dx.doi.org/10.1038/ijo.2009.47y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129068 |
856 | 4 8 | u https://doi.org/10.1038/ijo.2009.47 |
856 | 4 8 | u https://lup.lub.lu.se/record/1426005 |
856 | 4 8 | u https://research.chalmers.se/publication/93710 |
856 | 4 8 | u https://gup.ub.gu.se/publication/93710 |
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