Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.

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Fältnamn	Indikatorer	Metadata
000		13292naa a2201597 4500
001		oai:gup.ub.gu.se/330069
003		SwePub
008		240910s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:155109337
024	7	a https://gup.ub.gu.se/publication/3300692 URI
024	7	a https://doi.org/10.1210/clinem/dgad4632 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1551093372 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Teede, Helena J4 aut
245	1 0	a Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
264	1	c 2023
520		a What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference?International evidence-based guidelines address prioritized questions and outcomes and include 254 recommendations and practice points, to promote consistent, evidence-based care and improve the experience and health outcomes in PCOS.The 2018 International PCOS Guideline was independently evaluated as high quality and integrated multidisciplinary and consumer perspectives from six continents; it is now used in 196 countries and is widely cited. It was based on best available, but generally very low to low quality, evidence. It applied robust methodological processes and addressed shared priorities. The guideline transitioned from consensus based to evidence-based diagnostic criteria and enhanced accuracy of diagnosis, whilst promoting consistency of care. However, diagnosis is still delayed, the needs of those with PCOS are not being adequately met, evidence quality was low and evidence-practice gaps persist.The 2023 International Evidence-based Guideline update reengaged the 2018 network across professional societies and consumer organizations with multidisciplinary experts and women with PCOS directly involved at all stages. Extensive evidence synthesis was completed. Appraisal of Guidelines for Research and Evaluation-II (AGREEII)-compliant processes were followed. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework was applied across evidence quality, feasibility, acceptability, cost, implementation and ultimately recommendation strength and diversity and inclusion were considered throughout.This summary should be read in conjunction with the full Guideline for detailed participants and methods. Governance included a six-continent international advisory and management committee, five guideline development groups, and paediatric, consumer, and translation committees. Extensive consumer engagement and guideline experts informed the update scope and priorities. Engaged international society-nominated panels included paediatrics, endocrinology, gynaecology, primary care, reproductive endocrinology, obstetrics, psychiatry, psychology, dietetics, exercise physiology, obesity care, public health and other experts, alongside consumers, project management, evidence synthesis, statisticians and translation experts. Thirty-nine professional and consumer organizations covering 71 countries engaged in the process. Twenty meetings and five face-to-face forums over 12 months addressed 58 prioritized clinical questions involving 52 systematic and 3 narrative reviews. Evidence-based recommendations were developed and approved via consensus across five guideline panels, modified based on international feedback and peer review, independently reviewed for methodological rigour, and approved by the Australian Government National Health and Medical Research Council (NHMRC).The evidence in the assessment and management of PCOS has generally improved in the past five years, but remains of low to moderate quality. The technical evidence report and analyses (∼6000 pages) underpins 77 evidence-based and 54 consensus recommendations, with 123 practice points. Key updates include: i) further refinement of individual diagnostic criteria, a simplified diagnostic algorithm and inclusion of anti-Müllerian hormone (AMH) levels as an alternative to ultrasound in adults only; ii) strengthening recognition of broader features of PCOS including metabolic risk factors, cardiovascular disease, sleep apnea, very high prevalence of psychological features, and high risk status for adverse outcomes during pregnancy; iii) emphasizing the poorly recognized, diverse burden of disease and the need for greater healthcare professional education, evidence-based patient information, improved models of care and shared decision making to improve patient experience, alongside greater research; iv) maintained emphasis on healthy lifestyle, emotional wellbeing and quality of life, with awareness and consideration of weight stigma; and v) emphasizing evidence-based medical therapy and cheaper and safer fertility management.Overall, recommendations are strengthened and evidence is improved, but remain generally low to moderate quality. Significantly greater research is now needed in this neglected, yet common condition. Regional health system variation was considered and acknowledged, with a further process for guideline and translation resource adaptation provided.The 2023 International Guideline for the Assessment and Management of PCOS provides clinicians and patients with clear advice on best practice, based on the best available evidence, expert multidisciplinary input and consumer preferences. Research recommendations have been generated and a comprehensive multifaceted dissemination and translation programme supports the Guideline with an integrated evaluation program.This effort was primarily funded by the Australian Government via the National Health Medical Research Council (NHMRC) (APP1171592), supported by a partnership with American Society for Reproductive Medicine, Endocrine Society, European Society for Human Reproduction and Embryology, and the European Society for Endocrinology. The Commonwealth Government of Australia also supported Guideline translation through the Medical Research Future Fund (MRFCRI000266). HJT and AM are funded by NHMRC fellowships. JT is funded by a Royal Australasian College of Physicians (RACP) fellowship. Guideline development group members were volunteers. Travel expenses were covered by the sponsoring organizations. Disclosures of interest were strictly managed according to NHMRC policy and are available with the full guideline, technical evidence report, peer review and responses (www.monash.edu/medicine/mchri/pcos). Of named authors HJT, CTT, AD, LM, LR, JBoyle, AM have no conflicts of interest to declare. JL declares grant from Ferring and Merck; consulting fees from Ferring and Titus Health Care; speaker's fees from Ferring; unpaid consultancy for Ferring, Roche Diagnostics and Ansh Labs; and sits on advisory boards for Ferring, Roche Diagnostics, Ansh Labs, and Gedeon Richter. TP declares a grant from Roche; consulting fees from Gedeon Richter and Organon; speaker's fees from Gedeon Richter and Exeltis; travel support from Gedeon Richter and Exeltis; unpaid consultancy for Roche Diagnostics; and sits on advisory boards for Roche Diagnostics. MC declares travels support from Merck; and sits on an advisory board for Merck. JBoivin declares grants from Merck Serono Ltd.; consulting fees from Ferring B.V; speaker's fees from Ferring Arzneimittell GmbH; travel support from Organon; and sits on an advisory board for the Office of Health Economics. RJN has received speaker's fees from Merck and sits on an advisory board for Ferring. AJoham has received speaker's fees from Novo Nordisk and Boehringer Ingelheim. The guideline was peer reviewed by special interest groups across our 39 partner and collaborating organizations, was independently methodologically assessed against AGREEII criteria and was approved by all members of the guideline development groups and by the NHMRC.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a Pregnancy
653		a Adult
653		a Female
653		a Humans
653		a Child
653		a Polycystic Ovary Syndrome
653		a diagnosis
653		a therapy
653		a epidemiology
653		a Quality of Life
653		a Australia
653		a Risk Factors
653		a Infertility
653		a Female
653		a therapy
700	1	a Tay, Chau Thien4 aut
700	1	a Laven, Joop J E4 aut
700	1	a Dokras, Anuja4 aut
700	1	a Moran, Lisa J4 aut
700	1	a Piltonen, Terhi T4 aut
700	1	a Costello, Michael F4 aut
700	1	a Boivin, Jacky4 aut
700	1	a Redman, Leanne M4 aut
700	1	a Boyle, Jacqueline A4 aut
700	1	a Norman, Robert J4 aut
700	1	a Mousa, Aya4 aut
700	1	a Joham, Anju E4 aut
700	1	a Arlt, Wiebke4 aut
700	1	a Azziz, Ricardo4 aut
700	1	a Balen, Adam4 aut
700	1	a Bedson, Lisa4 aut
700	1	a Berry, Lorna4 aut
700	1	a Boivin, Jacky4 aut
700	1	a Boyle, Jacqueline4 aut
700	1	a Brennan, Leah4 aut
700	1	a Borwn, Wendy4 aut
700	1	a Burgert, Tania4 aut
700	1	a Busby, Maureen4 aut
700	1	a Ee, Carolyn4 aut
700	1	a Garad, Rhonda M4 aut
700	1	a Gibson-Helm, Melanie4 aut
700	1	a Harrison, Cheryce4 aut
700	1	a Hart, Roger4 aut
700	1	a Hopkins, Kim4 aut
700	1	a Lindén Hirschberg, Angelica4 aut
700	1	a Ho, Tuong4 aut
700	1	a Hoeger, Kathleen4 aut
700	1	a Jordan, Cailin4 aut
700	1	a Legro, Richard S4 aut
700	1	a Li, Rong4 aut
700	1	a Lujan, Maria4 aut
700	1	a Ma, Ronald4 aut
700	1	a Mansfield, Darren4 aut
700	1	a Marsh, Kate4 aut
700	1	a Mocanu, Edgar4 aut
700	1	a Mol, Ben4 aut
700	1	a Mormon, Rachel4 aut
700	1	a Norman, Robert4 aut
700	1	a Oberfield, Sharon4 aut
700	1	a Patel, Malika4 aut
700	1	a Pattuwage, Loyal4 aut
700	1	a Pena, Alexia4 aut
700	1	a Redman, Leanne4 aut
700	1	a Rombauts, Luk4 aut
700	1	a Romualdi, Daniela4 aut
700	1	a Shah, Duru4 aut
700	1	a Spritzer, Poli Mara4 aut
700	1	a Stener-Victorin, Elisabet,d 19644 aut
700	1	a Tehrani, Fahimeh Ramezani4 aut
700	1	a Thangaratinam, Shakila4 aut
700	1	a Thondan, Mala4 aut
700	1	a Vanky, Eszter4 aut
700	1	a Wijeyaratne, Chandrika4 aut
700	1	a Witchel, Selma4 aut
700	1	a Yang, Dongzi4 aut
700	1	a Yildiz, Bulent4 aut
700	1	a Alesi, Simon4 aut
700	1	a Alur-Gupta, Snigdha4 aut
700	1	a Avery, Jodie4 aut
700	1	a Bahri Khomami, Mahnaz4 aut
700	1	a Benham, Jamie4 aut
700	1	a Bidstrup, Hugh4 aut
700	1	a Chua, Su Jen4 aut
700	1	a Cooney, Laura4 aut
700	1	a Coster, Thiasara4 aut
700	1	a Fitz, Victoria4 aut
700	1	a Flanagan, Madeline4 aut
700	1	a Forslund, Maria,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xforss
700	1	a Jiskoot, Geranne4 aut
700	1	a Kazemi, Maryam4 aut
700	1	a Kempegowda, Puntih4 aut
700	1	a Louwers, Yvonne4 aut
700	1	a Melin, Johanna4 aut
700	1	a Melson, Eka4 aut
700	1	a Mengistu, Yitayeh Beltsi4 aut
700	1	a Naderpoor, Negar4 aut
700	1	a Neven, Adriana4 aut
700	1	a Pastoor, Hester4 aut
700	1	a Rocha, Thais4 aut
700	1	a Sabag, Angelo4 aut
700	1	a Subramanian, Anuradhaa4 aut
700	1	a Tan, Katrina4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org
773	0	t The Journal of clinical endocrinology and metabolismg 108:10, s. 2447-2469q 108:10<2447-2469x 1945-7197
856	4 8	u https://gup.ub.gu.se/publication/330069
856	4 8	u https://doi.org/10.1210/clinem/dgad463
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:155109337

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Av författaren/redakt...: Teede, Helena J; Tay, Chau Thien; Laven, Joop J E; Dokras, Anuja; Moran, Lisa J; Piltonen, Terhi ...; visa fler...; Costello, Michae ...; Boivin, Jacky; Redman, Leanne M; Boyle, Jacquelin ...; Norman, Robert J; Mousa, Aya; Joham, Anju E; Arlt, Wiebke; Azziz, Ricardo; Balen, Adam; Bedson, Lisa; Berry, Lorna; Boyle, Jacquelin ...; Brennan, Leah; Borwn, Wendy; Burgert, Tania; Busby, Maureen; Ee, Carolyn; Garad, Rhonda M; Gibson-Helm, Mel ...; Harrison, Cheryc ...; Hart, Roger; Hopkins, Kim; Lindén Hirschber ...; Ho, Tuong; Hoeger, Kathleen; Jordan, Cailin; Legro, Richard S; Li, Rong; Lujan, Maria; Ma, Ronald; Mansfield, Darre ...; Marsh, Kate; Mocanu, Edgar; Mol, Ben; Mormon, Rachel; Norman, Robert; Oberfield, Sharo ...; Patel, Malika; Pattuwage, Loyal; Pena, Alexia; Redman, Leanne; Rombauts, Luk; Romualdi, Daniel ...; Shah, Duru; Spritzer, Poli M ...; Stener-Victorin, ...; Tehrani, Fahimeh ...; Thangaratinam, S ...; Thondan, Mala; Vanky, Eszter; Wijeyaratne, Cha ...; Witchel, Selma; Yang, Dongzi; Yildiz, Bulent; Alesi, Simon; Alur-Gupta, Snig ...; Avery, Jodie; Bahri Khomami, M ...; Benham, Jamie; Bidstrup, Hugh; Chua, Su Jen; Cooney, Laura; Coster, Thiasara; Fitz, Victoria; Flanagan, Madeli ...; Forslund, Maria, ...; Jiskoot, Geranne; Kazemi, Maryam; Kempegowda, Punt ...; Louwers, Yvonne; Melin, Johanna; Melson, Eka; Mengistu, Yitaye ...; Naderpoor, Negar; Neven, Adriana; Pastoor, Hester; Rocha, Thais; Sabag, Angelo; Subramanian, Anu ...; Tan, Katrina; visa färre...

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