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Cardio-Hepatic Inte...
Cardio-Hepatic Interaction in Cardiac Amyloidosis
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- Ihne-Schubert, Sandra Michaela (författare)
- Lund University,Lunds universitet,CIRCLE,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,University Hospital Giessen and Marburg,University Hospital of Wϋrzburg
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- Goetze, Oliver (författare)
- University Hospital of Wϋrzburg,Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH
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- Gerstendörfer, Felix (författare)
- University Hospital of Wϋrzburg
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- Sahiti, Floran (författare)
- University Hospital of Wϋrzburg
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Schade, Ina (författare)
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- Papagianni, Aikaterini (författare)
- University Hospital of Wϋrzburg
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- Morbach, Caroline (författare)
- University Hospital of Wϋrzburg
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- Frantz, Stefan (författare)
- University Hospital of Wϋrzburg
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- Einsele, Hermann (författare)
- University Hospital of Wϋrzburg
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- Knop, Stefan (författare)
- University Hospital of Wϋrzburg
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- Sommer, Claudia (författare)
- University Hospital of Wϋrzburg
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- Müllhaupt, Beat (författare)
- University Hospital of Zurich
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- Schubert, Torben (författare)
- Lund University,Lunds universitet,CIRCLE,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Fraunhofer Institute for Systems and Innovation Research
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- Störk, Stefan (författare)
- University Hospital of Wϋrzburg
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- Geier, Andreas (författare)
- University Hospital of Wϋrzburg
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Journal of Clinical Medicine. - 2077-0383. ; 13:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Congestion is associated with poor prognosis in cardiac amyloidosis (CA). The cardio-hepatic interaction and the prognostic impact of secondary liver affection by cardiac congestion in CA are poorly understood and require further characterisation. Methods: Participants of the amyloidosis cohort study AmyKoS at the Interdisciplinary Amyloidosis Centre of Northern Bavaria with proven transthyretin (ATTR-CA) and light chain CA (AL-CA) underwent serial work-up including laboratory tests, echocardiography, and in-depth hepatic assessment by vibration-controlled transient elastography (VCTE) and 13C-methacetin breath test. Results: In total, 74 patients with AL-CA (n = 17), ATTR-CA (n = 26) and the controls (n = 31) were analysed. ATTR-CA patients showed decreased microsomal liver function expressed by maximal percentage of dose rate (PDRpeak) related to hepatic congestion. Reduced PDRpeak in AL-CA could result from altered pharmacokinetics due to changed hepatic blood flow. Liver stiffness as a combined surrogate of chronic liver damage and congestion was identified as a predictor of all-cause mortality. Statistical modelling of the cardio-hepatic interaction revealed septum thickness, NT-proBNP and PDRpeak as predictors of liver stiffness in both CA subtypes; dilatation of liver veins and the fibrosis score FIB-4 were only significant for ATTR-CA. Conclusions: Non-invasive methods allow us to characterise CA-associated hepatic pathophysiology. Liver stiffness might be promising for risk stratification in CA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- C-methacetin breath test (MBT)
- cardiac amyloidosis
- congestion
- liver stiffness
- PDR
- vibration-controlled transient elastography (VTCE)
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Ihne-Schubert, S ...
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Goetze, Oliver
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Gerstendörfer, F ...
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Sahiti, Floran
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Schade, Ina
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Papagianni, Aika ...
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Morbach, Carolin ...
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Frantz, Stefan
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Einsele, Hermann
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Knop, Stefan
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Sommer, Claudia
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Müllhaupt, Beat
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Schubert, Torben
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Störk, Stefan
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Geier, Andreas
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Journal of Clini ...
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Lunds universitet