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Effects of calcium,...
Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial.
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Cheng, Sulin (author)
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Lyytikäinen, Arja (author)
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Kröger, Heikki (author)
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Lamberg-Allardt, Christel (author)
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Alén, Markku (author)
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Koistinen, Arvo (author)
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Wang, Qing Ju (author)
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Suuriniemi, Miia (author)
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Suominen, Harri (author)
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Mahonen, Anitta (author)
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Nicholson, Patrick H F (author)
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Ivaska, Kaisa K (author)
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Korpela, Riitta (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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Väänänen, Kalervo H (author)
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Tylavsky, Frances (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: The American journal of clinical nutrition. - 0002-9165. ; 82:5
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. OBJECTIVE: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. DESIGN: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography. RESULTS: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared. CONCLUSIONS: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.
Keyword
- Absorptiometry
- Photon
- Analysis of Variance
- Body Composition
- drug effects
- physiology
- Bone Density
- drug effects
- physiology
- Bone Density Conservation Agents
- pharmacology
- Bone Development
- drug effects
- physiology
- Bone Remodeling
- Calcium
- Dietary
- pharmacology
- Cheese
- Child
- Dairy Products
- Dietary Supplements
- Double-Blind Method
- Female
- Humans
- Linear Models
- Menarche
- physiology
- Patient Compliance
- Puberty
- physiology
- Radius
- radiography
- Tibia
- radiography
- Vitamin D
- pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cheng, Sulin
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Lyytikäinen, Arj ...
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Kröger, Heikki
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Lamberg-Allardt, ...
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Alén, Markku
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Koistinen, Arvo
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show more...
-
Wang, Qing Ju
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Suuriniemi, Miia
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Suominen, Harri
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Mahonen, Anitta
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Nicholson, Patri ...
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Ivaska, Kaisa K
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Korpela, Riitta
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Ohlsson, Claes, ...
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Väänänen, Kalerv ...
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Tylavsky, France ...
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show less...
- Articles in the publication
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The American jou ...
- By the university
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University of Gothenburg