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Sökning: WFRF:(Kruger Iolanthé M) > (2019) > Joint association o...

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FältnamnIndikatorerMetadata
00005886naa a2200973 4500
001oai:gup.ub.gu.se/285579
003SwePub
008240910s2019 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2855792 URI
0247 a https://doi.org/10.1136/bmj.l7722 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a O'Donnell, Martin4 aut
2451 0a Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
264 c 2019-03-13
264 1b BMJ,c 2019
520 a To evaluate the joint association of sodium and potassium urinary excretion (as surrogate measures of intake) with cardiovascular events and mortality, in the context of current World Health Organization recommendations for daily intake (<2.0 g sodium, >3.5 g potassium) in adults.International prospective cohort study.18 high, middle, and low income countries, sampled from urban and rural communities.103570 people who provided morning fasting urine samples.Association of estimated 24 hour urinary sodium and potassium excretion (surrogates for intake) with all cause mortality and major cardiovascular events, using multivariable Cox regression. A six category variable for joint sodium and potassium was generated: sodium excretion (low (<3 g/day), moderate (3-5 g/day), and high (>5 g/day) sodium intakes) by potassium excretion (greater/equal or less than median 2.1 g/day).Mean estimated sodium and potassium urinary excretion were 4.93 g/day and 2.12 g/day, respectively. After a median follow-up of 8.2 years, 7884 (6.1%) participants had died or experienced a major cardiovascular event. Increasing urinary sodium excretion was positively associated with increasing potassium excretion (unadjusted r=0.34), and only 0.002% had a concomitant urinary excretion of <2.0 g/day of sodium and >3.5 g/day of potassium. A J-shaped association was observed of sodium excretion and inverse association of potassium excretion with death and cardiovascular events. For joint sodium and potassium excretion categories, the lowest risk of death and cardiovascular events occurred in the group with moderate sodium excretion (3-5 g/day) and higher potassium excretion (21.9% of cohort). Compared with this reference group, the combinations of low potassium with low sodium excretion (hazard ratio 1.23, 1.11 to 1.37; 7.4% of cohort) and low potassium with high sodium excretion (1.21, 1.11 to 1.32; 13.8% of cohort) were associated with the highest risk, followed by low sodium excretion (1.19, 1.02 to 1.38; 3.3% of cohort) and high sodium excretion (1.10, 1.02 to 1.18; 29.6% of cohort) among those with potassium excretion greater than the median. Higher potassium excretion attenuated the increased cardiovascular risk associated with high sodium excretion (P for interaction=0.007).These findings suggest that the simultaneous target of low sodium intake (<2 g/day) with high potassium intake (>3.5 g/day) is extremely uncommon. Combined moderate sodium intake (3-5 g/day) with high potassium intake is associated with the lowest risk of mortality and cardiovascular events.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Aged
653 a Cardiovascular Diseases
653 a epidemiology
653 a etiology
653 a urine
653 a Female
653 a Follow-Up Studies
653 a Humans
653 a Male
653 a Middle Aged
653 a Mortality
653 a Potassium
653 a urine
653 a Potassium
653 a Dietary
653 a administration & dosage
653 a adverse effects
653 a Prospective Studies
653 a Sodium
653 a urine
653 a Sodium
653 a Dietary
653 a administration & dosage
653 a adverse effects
7001 a Mente, Andrew4 aut
7001 a Rangarajan, Sumathy4 aut
7001 a McQueen, Matthew J4 aut
7001 a O'Leary, Neil4 aut
7001 a Yin, Lu4 aut
7001 a Liu, Xiaoyun4 aut
7001 a Swaminathan, Sumathi4 aut
7001 a Khatib, Rasha4 aut
7001 a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xrosan
7001 a Ferguson, John4 aut
7001 a Smyth, Andrew4 aut
7001 a Lopez-Jaramillo, Patricio4 aut
7001 a Diaz, Rafael4 aut
7001 a Avezum, Alvaro4 aut
7001 a Lanas, Fernando4 aut
7001 a Ismail, Noorhassim4 aut
7001 a Yusoff, Khalid4 aut
7001 a Dans, Antonio4 aut
7001 a Iqbal, Romaina4 aut
7001 a Szuba, Andrzej4 aut
7001 a Mohammadifard, Noushin4 aut
7001 a Oguz, Atyekin4 aut
7001 a Yusufali, Afzal Hussein4 aut
7001 a Alhabib, Khalid F4 aut
7001 a Kruger, Iolanthe M4 aut
7001 a Yusuf, Rita4 aut
7001 a Chifamba, Jephat4 aut
7001 a Yeates, Karen4 aut
7001 a Dagenais, Gilles4 aut
7001 a Wielgosz, Andreas4 aut
7001 a Lear, Scott A4 aut
7001 a Teo, Koon4 aut
7001 a Yusuf, Salim4 aut
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
7730 t BMJ (Clinical research ed.)d : BMJg 364q 364x 1756-1833x 0959-8138
8564 u https://www.bmj.com/content/bmj/364/bmj.l772.full.pdf
8564 8u https://gup.ub.gu.se/publication/285579
8564 8u https://doi.org/10.1136/bmj.l772

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