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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03892naa a2200805 4500 | |
| 001 | oai:lup.lub.lu.se:f63e150d-4892-43a0-880e-279785140789 | |
| 003 | SwePub | |
| 008 | 160401s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/3007322 URI |
| 024 | 7 | a https://doi.org/10.1160/TH02-11-02642 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Look, M4 aut |
| 245 | 1 0 | a Pooled analysis of prognostic impact of uPA and PAI-I in breast cancer patients |
| 264 | 1 | c 2003 |
| 520 | a In this report we present an extension of the pooled analysis of the prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I in breast cancer patients. We analyzed a different endpoint, metastasis-free survival (MFS). We checked the consistency of the estimates for uPA and PAI-I for relapse-free survival (RFS) and MFS exploring possible sources of heterogeneity. Nodal status, the most important prognostic factor for breast cancer, introduced heterogeneity in the uPA/PAI-I survival analyses, reflecting the interaction between nodal status and uPA/PAI-I. The estimates for uPA and PAI-I were found to be consistent, even when a different transformation of their values was used. The heterogeneity of the separate data sets decreased if the levels of uPA and PAI-I were ranked, data sets were pooled, and the analyses corrected for the base model that included all traditional prognostic factors, and stratified by data set. We conclude that uPA and PAI-I are ready to be used in the clinic to help classify breast cancer patients into high and low risk groups. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a breast cancer | |
| 653 | a PAI-I | |
| 653 | a pooled-analysis | |
| 653 | a uPA | |
| 653 | a prognosis | |
| 700 | 1 | a van Putten, W4 aut |
| 700 | 1 | a Duffy, M4 aut |
| 700 | 1 | a Harbeck, N4 aut |
| 700 | 1 | a Christensen, IJ4 aut |
| 700 | 1 | a Thomssen, C4 aut |
| 700 | 1 | a Kates, R4 aut |
| 700 | 1 | a Spyratos, F4 aut |
| 700 | 1 | a Fernö, Mårtenu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-mfe |
| 700 | 1 | a Eppenberger-Castori, S4 aut |
| 700 | 1 | a Sweep, CGJF4 aut |
| 700 | 1 | a Ulm, K4 aut |
| 700 | 1 | a Peyrat, JP4 aut |
| 700 | 1 | a Martin, PM4 aut |
| 700 | 1 | a Magdelenat, H4 aut |
| 700 | 1 | a Brunner, N4 aut |
| 700 | 1 | a Duggan, C4 aut |
| 700 | 1 | a Lisboa, BW4 aut |
| 700 | 1 | a Bendah, PO4 aut |
| 700 | 1 | a Quillien, V4 aut |
| 700 | 1 | a Daver, A4 aut |
| 700 | 1 | a Ricolleau, G4 aut |
| 700 | 1 | a Meijer-Van Gelder, M4 aut |
| 700 | 1 | a Manders, P4 aut |
| 700 | 1 | a Fiets, WE4 aut |
| 700 | 1 | a Blankenstein, M4 aut |
| 700 | 1 | a Broet, P4 aut |
| 700 | 1 | a Romain, S4 aut |
| 700 | 1 | a Daxenbichler, G4 aut |
| 700 | 1 | a Windbichler, G4 aut |
| 700 | 1 | a Cufer, T4 aut |
| 700 | 1 | a Borstnar, S4 aut |
| 700 | 1 | a Kueng, W4 aut |
| 700 | 1 | a Beex, L4 aut |
| 700 | 1 | a Klijn, J4 aut |
| 700 | 1 | a O'Higgins, N4 aut |
| 700 | 1 | a Eppenberger, U4 aut |
| 700 | 1 | a Janicke, F4 aut |
| 700 | 1 | a Schmitt, M4 aut |
| 700 | 1 | a Foekens, J4 aut |
| 710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
| 773 | 0 | t Thrombosis and Haemostasisg 90:3, s. 538-548q 90:3<538-548x 0340-6245 |
| 856 | 4 | u http://dx.doi.org/10.1160/TH02-11-0264y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/300732 |
| 856 | 4 8 | u https://doi.org/10.1160/TH02-11-0264 |
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- Look, M
- van Putten, W
- Duffy, M
- Harbeck, N
- Christensen, IJ
- Thomssen, C
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- Kates, R
- Spyratos, F
- Fernö, Mårten
- Eppenberger-Cast ...
- Sweep, CGJF
- Ulm, K
- Peyrat, JP
- Martin, PM
- Magdelenat, H
- Brunner, N
- Duggan, C
- Lisboa, BW
- Bendah, PO
- Quillien, V
- Daver, A
- Ricolleau, G
- Meijer-Van Gelde ...
- Manders, P
- Fiets, WE
- Blankenstein, M
- Broet, P
- Romain, S
- Daxenbichler, G
- Windbichler, G
- Cufer, T
- Borstnar, S
- Kueng, W
- Beex, L
- Klijn, J
- O'Higgins, N
- Eppenberger, U
- Janicke, F
- Schmitt, M
- Foekens, J
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