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Associations of Pre...
Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever
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Kuiper, I. N. (author)
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Markevych, I. (author)
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Accordini, S. (author)
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Bertelsen, R. J. (author)
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- Bråbäck, Lennart (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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Christensen, J. H. (author)
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- Forsberg, Bertil (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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Halvorsen, T. (author)
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Heinrich, J. (author)
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Hertel, O. (author)
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Hoek, G. (author)
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- Holm, Mathias, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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de Hoogh, K. (author)
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi
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Marcon, A. (author)
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Sigsgaard, T. (author)
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Svanes, C. (author)
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Johannessen, A. (author)
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(creator_code:org_t)
- 2020-08-12
- 2020
- English.
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In: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1660-4601 .- 1661-7827. ; 17:16
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https://doi.org/10.3...
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Abstract
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- We investigated if greenness and air pollution exposure in parents' childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM(2.5)and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O-3) (mu g/m(3)) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0-18 years old and offspring 0-10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM(2.5)and PM(10)exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32-3.78, OR 2.27, 95%CI 1.36-3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11-0.87). Hay fever risk increased for offspring of fathers with medium O(3)exposure (OR 4.15, 95%CI 1.28-13.50) and mothers with high PM(10)exposure (OR 2.66, 95%CI 1.19-5.91). The effect of maternal PM(10)exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring's own exposures. Paternal O(3)exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- air pollution
- greenness
- preconception exposure
- childhood asthma
- childhood hay fever
- residential greenness
- childhood asthma
- children
- no2
- greenspace
- mortality
- benefits
- smoking
- europe
- models
- Environmental Sciences & Ecology
- Public
- Environmental & Occupational
- Health
- air pollution
- Lungmedicin
- Fysiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kuiper, I. N.
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Markevych, I.
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Accordini, S.
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Bertelsen, R. J.
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Bråbäck, Lennart
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Christensen, J. ...
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show more...
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Forsberg, Bertil
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Halvorsen, T.
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Heinrich, J.
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Hertel, O.
-
Hoek, G.
-
Holm, Mathias, 1 ...
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de Hoogh, K.
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Janson, Christer
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Malinovschi, And ...
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Marcon, A.
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Sigsgaard, T.
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Svanes, C.
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Johannessen, A.
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show less...
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University of Gothenburg
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Umeå University
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Uppsala University