On no man's land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents

On no man's land : Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents

Radek, Linda (författare): Turku PET Centre, Turku University Hospital and University of Turku, Finland

Koskinen, Lauri (författare): Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland

Sandman, Nils (författare): Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland

Laaksonen, Lauri (författare): Turku PET Centre, Turku University Hospital and University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland

Kallionpää, Roosa E. (författare): Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland

Scheinin, Annalotta (författare): Turku PET Centre, Turku University Hospital and University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland

Rajala, Ville (författare): Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland

Maksimow, Anu (författare): Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland

Laitio, Timo (författare): Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland

Revonsuo, Antti (författare): Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience

Scheinin, Harry (författare): Turku PET Centre, Turku University Hospital and University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland ; Institute of Biomedicine and Unit of Clinical Pharmacology, University of Turku and Turku University Hospital, Finland

Valli, Katja, 1973- (författare): Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience

(creator_code:org_t)

Elsevier, 2021
2021
Engelska.
Ingår i: Consciousness and Cognition. - : Elsevier. - 1053-8100 .- 1090-2376. ; 96

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://his.diva-por... (primary) (Raw object); https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

To understand how anesthetics with different molecular mechanisms affect consciousness, we explored subjective experiences recalled after responsive and unresponsive sedation induced with equisedative doses of dexmedetomidine, propofol, sevoflurane, and S-ketamine in healthy male participants (N = 140). The anesthetics were administered in experimental setting using target-controlled infusion or vapouriser for one hour. Interviews conducted after anesthetic administration revealed that 46.9% (n = 46) of arousable participants (n = 98) reported experiences, most frequently dreaming or memory incorporation of the setting. Participants receiving dexmedetomidine reported experiences most often while S-ketamine induced the most multimodal experiences. Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology (hsv//eng)

Av författaren/redakt...: Radek, Linda; Koskinen, Lauri; Sandman, Nils; Laaksonen, Lauri; Kallionpää, Roos ...; Scheinin, Annalo ...; visa fler...; Rajala, Ville; Maksimow, Anu; Laitio, Timo; Revonsuo, Antti; Scheinin, Harry; Valli, Katja, 19 ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Anestesi och int ...

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