WFRF:(Lam Thua Phong)
Sökning: WFRF:(Lam Thua Phong) > Flavonoids as dual-...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04295naa a2200493 4500 | |
| 001 | oai:DiVA.org:uu-521221 | |
| 003 | SwePub | |
| 008 | 240122s2024 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5212212 URI |
| 024 | 7 | a https://doi.org/10.1007/s13659-023-00424-w2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Lam, Thua-Phongu Uppsala universitet,Institutionen för farmaci,Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 245 | 1 0 | a Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase :b a systematic review of in vitro studies |
| 264 | 1 | b Springer,c 2024 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on alpha-glucosidase and alpha-amylase, two key enzymes involved in starch digestion. Six scientific databases (PubMed, Virtual Health Library, EMBASE, SCOPUS, Web of Science, and WHO Global Index Medicus) were searched until August 21, 2022, for in vitro studies reporting IC50 values of purified flavonoids on alpha-amylase and alpha-glucosidase, along with corresponding data for acarbose as a positive control. A total of 339 eligible articles were analyzed, resulting in the retrieval of 1643 flavonoid structures. These structures were rigorously standardized and curated, yielding 974 unique compounds, among which 177 flavonoids exhibited inhibition of both alpha-glucosidase and alpha-amylase are presented. Quality assessment utilizing a modified CONSORT checklist and structure-activity relationship (SAR) analysis were performed, revealing crucial features for the simultaneous inhibition of flavonoids against both enzymes. Moreover, the review also addressed several limitations in the current research landscape and proposed potential solutions. The curated datasets are available online at https://github.com/MedChemUMP/FDIGA. | |
| 650 | 7 | a LANTBRUKSVETENSKAPERx Lantbruksvetenskap, skogsbruk och fiskex Livsmedelsvetenskap0 (SwePub)401032 hsv//swe |
| 650 | 7 | a AGRICULTURAL SCIENCESx Agriculture, Forestry and Fisheriesx Food Science0 (SwePub)401032 hsv//eng |
| 653 | a Systematic review | |
| 653 | a Flavonoids | |
| 653 | a Dual-target | |
| 653 | a Glucosidase | |
| 653 | a Amylase | |
| 653 | a PRISMA | |
| 653 | a SAR | |
| 700 | 1 | a Tran, Ngoc-Vi Nguyenu Uppsala universitet,Institutionen för farmaci,Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 700 | 1 | a Pham, Long-Hung Dinhu Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.;Imperial Coll London, Dept Chem, London W12 0BZ, England.4 aut |
| 700 | 1 | a Lai, Nghia Vo-Trongu Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 700 | 1 | a Dang, Bao-Tran Ngocu Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 700 | 1 | a Truong, Ngoc-Lam Nguyenu Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 700 | 1 | a Nguyen-Vo, Song-Kyu Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 700 | 1 | a Hoang, Thuy-Linhu Calif Northstate Univ, Coll Pharm, Elk Grove, CA 95757 USA.4 aut |
| 700 | 1 | a Mai, Tan Thanhu Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 700 | 1 | a Tran, Thanh-Daou Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för farmaci4 org |
| 773 | 0 | t NATURAL PRODUCTS AND BIOPROSPECTINGd : Springerg 14:1q 14:1x 2192-2195x 2192-2209 |
| 856 | 4 | u https://doi.org/10.1007/s13659-023-00424-wy Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1830011/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521221 |
| 856 | 4 8 | u https://doi.org/10.1007/s13659-023-00424-w |
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