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WFRF:(Leary Sophie E. C.)
 

Sökning: WFRF:(Leary Sophie E. C.) > Yersinia outer prot...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004519naa a2200481 4500
001oai:DiVA.org:umu-53000
003SwePub
008120309s1999 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-530002 URI
0247 a https://doi.org/10.1006/mpat.1998.02612 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Leary, Sophie E. C.u Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire, SP4 0JQ, U.K.4 aut
2451 0a Yersinia outer proteins (YOPS) E, K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague
264 1b Elsevier,c 1999
338 a print2 rdacarrier
520 a The pathogenic Yersiniae produce a range of virulence proteins, encoded by a 70 kb plasmid, which are essential for infection, and also form part of a contact-dependent virulence mechanism. One of these proteins, V antigen, has been shown to confer a high level of protection against parenteral infection with Y. pestis in murine models, and is considered to be a protective antigen. In this study, the protective efficacy of V antigen has been compared in the same model with that of other proteins (YopE, YopK and YopN), which are part of the contact-dependent virulence mechanism. Mice immunised with two intraperitoneal doses of V antigen or each of the Yops, administered with either Alhydrogel or interleukin-12, produced high antigen-specific serum IgG titres. As shown in previous studies, V+Alhydrogel was fully protective, and 5/5 mice survived a subcutaneous challenge with 90 or 9x10(3) LD50's of Y. pestis GB. In addition, these preliminary studies also showed that V+IL-12 was partially protective: 4/5 or 3/5 mice survived a challenge with 90 or 9x10(3) LD50's, respectively. In contrast, none of the mice immunised with the Yops survived the challenges, and there was no significant delay in the mean time to death compared to mice receiving a control protein. These results show that using two different vaccine regimens, Yops E, K and N, failed to elicit protective immune responses in a murine model of plague, whereas under the same conditions, V antigen was fully or partially protective.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
653 a V antigen
653 a LcrV
653 a Yops
653 a Yersinia
653 a plague
653 a interleukin-12
7001 a Griffin, Kate F.u Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire, SP4 0JQ, U.K.4 aut
7001 a Galyov, Edouard E.u Institute for Animal Health, Compton, Nr Newbury, Berkshire RG20 7NN, U.K.4 aut
7001 a Hewer, Jasonu Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire, SP4 0JQ, U.K.4 aut
7001 a Williamson, E. Dianeu Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire, SP4 0JQ, U.K.4 aut
7001 a Holmström, Annau Department of Microbiology, Defence Research Establishment, S-901 87 Umeå, Sweden4 aut0 (Swepub:umu)anho0141
7001 a Forsberg, Åke Forsbergu Department of Microbiology, Defence Research Establishment, S-901 87 Umeå, Sweden4 aut
7001 a Titball, Richard W.u Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire, SP4 0JQ, U.K.4 aut
7102 a Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire, SP4 0JQ, U.K.b Institute for Animal Health, Compton, Nr Newbury, Berkshire RG20 7NN, U.K.4 org
7730 t Microbial Pathogenesisd : Elsevierg 26:3, s. 159-169q 26:3<159-169x 0882-4010x 1096-1208
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53000
8564 8u https://doi.org/10.1006/mpat.1998.0261

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