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0247 a https://doi.org/10.1016/S2589-7500(22)00095-42 DOI
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041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mechler, Jakobu Stockholm University4 aut
2451 0a Therapist-guided internet-based psychodynamic therapy versus cognitive behavioural therapy for adolescent depression in Sweden :b a randomised, clinical, non-inferiority trial
264 1b Elsevier,c 2022
338 a print2 rdacarrier
500 a FUNDING: Kavli trust.
500 a Funding: Kavli trust
520 a Background Adolescent major depressive disorder (MDD) is highly prevalent and associated with lifelong adversity. Evidence-based treatments exist, but accessible treatment alternatives are needed. We aimed to compare internet-based psychodynamic therapy (IPDT) with an established evidence-based treatment (internet-based cognitive behavioural therapy [ICBT]) for the treatment of adolescents with depression. Methods In this randomised, clinical trial, we tested whether IPDT was non-inferior to ICBT in the treatment of adolescent MDD. Eligible participants were 15-19 years old, presenting with a primary diagnosis of MDD according to DSM-5. Participants were recruited nationwide in Sweden through advertisements on social media, as well as contacts with junior and senior high schools, youth associations, social workers, and health-care providers. Adolescents who scored 9 or higher on the Quick Inventory of Depressive Symptomatology for Adolescents (QIDS-A17-SR) in an initial online screening were contacted by telephone for a diagnostic assessment using the Mini International Neuropsychiatric Interview. Participants were randomly assigned to ICBT or IPDT. Both interventions comprised eight self-help modules delivered over 10 weeks on a secure online platform. The primary outcome was change in depression severity measured weekly by the QIDS-A17-SR. Primary analyses were based on an intention -to-treat sample including all participants randomly assigned. A non-inferiority margin of Cohen's d=0.30 was predefined. The study is registered at ISRCTN, ISRCTN12552584. Findings Between Aug 19, 2019, and Oct 7, 2020, 996 young people completed screening; 516 (52%) were contacted for a diagnostic interview. 272 participants were eligible and randomly assigned to ICBT (n=136) or IPDT (n=136). In the ICBT group, 51 (38%) of 136 participants were classified as remitted, and 54 (40%) of 136 participants were classified as remitted in the IPDT group. Within-group effects were large (ICBT: within-group d=1.75, 95% CI 1.49 to 2.01; IPDT: within-group d=1.93, 1.67 to 2.20; both p<0.0001). No statistically significant treatment difference was found in the intention-to-treat analysis. Non-inferiority for IPDT was shown for the estimated change in depression during treatment (d=-0.18, 90% CI -0.49 to 0.13; p=0.34). All secondary outcomes showed non-significant between-group differences. Interpretation IPDT was non-inferior to ICBT in terms of change in depression for the treatment of adolescents with MDD. This finding increases the range of accessible and effective treatment alternatives for adolescents with depression. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
650 7a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe
650 7a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a SAMHÄLLSVETENSKAPx Psykologix Tillämpad psykologi0 (SwePub)501022 hsv//swe
650 7a SOCIAL SCIENCESx Psychologyx Applied Psychology0 (SwePub)501022 hsv//eng
653 a Psychology
653 a Psykologi
7001 a Lindqvist, Karinu Stockholm University4 aut
7001 a Carlbring, Peru Stockholm University4 aut
7001 a Topooco, Naira,d 1980-u Linköping University,Linköpings universitet,Psykologi,Filosofiska fakulteten,Center for m2Health, Palo Alto University, CA, USA,Internet, health and clinical psychology research group4 aut0 (Swepub:liu)naito42
7001 a Falkenström, Fredrik,d 1972-u Linnaeus University,Linköpings universitet,Linnéuniversitetet,Institutionen för psykologi (PSY),Linköping University, Sweden,Linköping Univ, Dept Behav Sdences & Learning, Linköping, Sweden.;Linnaeus Univ, Dept Psychol, Växjö, Sweden.,Psykologi,Filosofiska fakulteten,Department of Psychology, Linnaeus University, Växjö, Sweden,Internet, health and clinical psychology research group4 aut0 (Swepub:liu)frefa24
7001 a Lilliengren, Peter,d 1972-u Ersta Sköndal Bräcke högskola,S:t Lukas utbildningsinstitut,Ersta Sköndal Bräcke University College, Stockholm, Sweden4 aut0 (Swepub:esh)petlil
7001 a Andersson, Gerhard,d 1966-u Karolinska Institute,Linköpings universitet,Karolinska Institutet,Linköping University,Psykologi,Filosofiska fakulteten,Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden,Internet, health and clinical psychology research group4 aut0 (Swepub:liu)geran87
7001 a Johansson, Robertu Stockholm University4 aut
7001 a Midgley, Nicku Anna Freud Natl Ctr Children & Families, Child Attachment & Psychol Therapies Res Unit, London, England.;UCL, Dept Clin Educ & Hlth Psychol, London, England.,Anna Freud National Centre for Children and Families, United Kingdom; University College London, United Kingdom,Child Attachment and Psychological Therapies Research Unit, Anna Freud National Centre for Children and Families, London, UK4 aut
7001 a Edbrooke-Childs, Julianu Anna Freud Natl Ctr Children & Families, Evidence Based Practice Unit, London, England.;UCL, Dept Clin Educ & Hlth Psychol, London, England.,Anna Freud National Centre for Children and Families, United Kingdom; University College London, United Kingdom,Evidence-based Practice Unit, Anna Freud National Centre for Children and Families, London, UK and Department of Clinical, Educational and Health Psychology, University College London, London, UK4 aut
7001 a Dahl, Hanne-Sofie J.u Univ Oslo, Dept Psychol, Oslo, Norway.,Department of Psychology, University of Oslo, Oslo, Norway4 aut
7001 a Sandell, Rolfu Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences4 aut0 (Swepub:lu)ro6305sa
7001 a Thoren, Agnetau The Erica Foundation, Stockholm, Sweden,Erica Fdn, Stockholm, Sweden.,Ericastiftelsen, Stockholm4 aut
7001 a Ulberg, Randiu Univ Oslo, Inst Clin Med, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat, Oslo, Norway.,Institute of Clinical Medicine, University of Oslo, Oslo, Norway and Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway4 aut
7001 a Lindert Bergsten, Katjau Uppsala University,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)katjclae
7001 a Philips, Bjornu Stockholm University4 aut
7102 a Stockholm Universityb Psykologi4 org
7730 t The Lancet Digital Healthd : Elsevierg 4:8, s. E594-E603q 4:8<E594-E603x 2589-7500
8564 u https://doi.org/10.1016/S2589-7500(22)00095-4y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1716175/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://liu.diva-portal.org/smash/get/diva2:1701929/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1016/S2589-7500(22)00095-4x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-117499
8564 8u https://doi.org/10.1016/S2589-7500(22)00095-4
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8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189031
8564 8u https://lup.lub.lu.se/record/18459b08-3b7f-4f93-b1c3-66dd41d4e9b5

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