WFRF:(Lindholm Lena)
Sökning: WFRF:(Lindholm Lena) > (1985-1989) > Cystatin C : a new ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03972naa a2200469 4500 | |
| 001 | oai:lup.lub.lu.se:f1910299-69f2-47a5-b3a3-be4196e71532 | |
| 003 | SwePub | |
| 008 | 211027s1988 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/f1910299-69f2-47a5-b3a3-be4196e715322 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Thysell, Hansu Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)njur-hth |
| 245 | 1 0 | a Cystatin C : a new marker of biocompatibility or a good marker for the redistribution of LMW proteins during hemodialysis? |
| 264 | 1 | c 1988 |
| 520 | a The mechanism(s) behind the larger relative increase of Plasma beta 2 microglobulin (P-beta 2m) than that of Plasma albumin (P-alb) during Cuprophan hemodialysis is disputed. To elucidate this phenomenon P-alb, P-beta 2m (MW 11,800) and Plasma cystatin (P-cC; MW 13,000) an inhibitor of cystein proteinases, were determined before and after a Cuprophan or polysulphone hemodialysis (4-7 hr, QB 200 ml/min) in 30 stable regular dialysis treatment (RDT) patients. Body weight (BW) decreased by 2.5 +/- 1.4% (mean +/- SD). P-alb, P-beta 2m and P-cC increased by 11.4 +/- 14.8%, 15.4 +/- 11.5%, and 22.1 +/- 14.3%, respectively, during Cuprophan dialysis. The relative increase of P-cC was larger than that of P-beta 2m (P less than 0.05) and that of P-alb (P less than 0.02). During polysulphone dialysis BW decreased by 4.1 +/- 1.8%. P-alb, P-beta 2m, and P-cC increased almost equally by 28.1 +/- 18, 26.5 +/- 19.2, and 26.8 +/- 14.4%, respectively. These results are hard to interpret. Is the increase in P-cC a new marker of biocompatibility or does it reflect the true shift of low molecular weight (LMW) proteins between the interstitial and the plasma volume during hemodialysis better than P-beta 2m? In vitro studies indicate that small amounts of both Serum beta 2m (S-beta 2m) and Serum cystatin C (S-cC) are adsorbed to or sieved through the Cuprophan membrane, findings which render the kinetics of LMW proteins during hemodialysis still more complex. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
| 653 | a Biocompatible Materials | |
| 653 | a Blood Proteins | |
| 653 | a Body Weight | |
| 653 | a Cellulose/analogs & derivatives | |
| 653 | a Cystatin C | |
| 653 | a Cystatins | |
| 653 | a Humans | |
| 653 | a Membranes, Artificial | |
| 653 | a Polymers | |
| 653 | a Protease Inhibitors/blood | |
| 653 | a Renal Dialysis | |
| 653 | a Serum Albumin/analysis | |
| 653 | a Sulfones | |
| 653 | a beta 2-Microglobulin/analysis | |
| 700 | 1 | a Grubb, Andersu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kkem-agr |
| 700 | 1 | a Lindholm, Tore4 aut |
| 700 | 1 | a Ljunggren, Lennart4 aut |
| 700 | 1 | a Mårtensson, Lena4 aut |
| 710 | 2 | a Njurmedicinb Sektion II4 org |
| 773 | 0 | t ASAIO Transactionsg 34:3, s. 202-204q 34:3<202-204x 0889-7190 |
| 856 | 4 | u https://journals.lww.com/asaiojournal/Abstract/1988/07000/Cystatin_C__A_New_Marker_of_Biocompatibility_or_a.12.aspxx freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/f1910299-69f2-47a5-b3a3-be4196e71532 |
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