Sökning: WFRF:(Lipton Jack) > Behavioural and neu...
Fältnamn | Indikatorer | Metadata |
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000 | 03150naa a2200409 4500 | |
001 | oai:lup.lub.lu.se:a8fa48b0-05e2-460a-ae42-804fa029b239 | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/80432432 URI |
024 | 7 | a https://doi.org/10.1186/s12974-015-0387-42 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Bay-Richter, Cecilie4 aut |
245 | 1 0 | a Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice. |
264 | c 2015-09-04 | |
264 | 1 | b Springer Science and Business Media LLC,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Evidence from clinical studies and animal models show that inflammation can lead to the development of depression. Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine that is synthesized by several cell types in the brain. MIF can increase production of other cytokines, activates cyclooxygenase (COX)-2 and can counter-regulate anti-inflammatory effects of glucocorticoids. Increased plasma levels of MIF are associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and depressive symptoms in patients. In contrast, MIF knockout (KO) mice have been found to exhibit increased depressive-like behaviour. The exact role for MIF in depression is therefore still controversial. To further understand the role of MIF in depression, we studied depressive-like behaviour in congenic male and female MIF KO mice and wild-type (WT) littermates and the associated neurobiological mechanisms underlying the behavioural outcome. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Janelidze, Shorenau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)nkir-sje |
700 | 1 | a Sauro, Analise4 aut |
700 | 1 | a Bucala, Richard4 aut |
700 | 1 | a Lipton, Jack4 aut |
700 | 1 | a Deierborg, Tomasu Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)expb-tol |
700 | 1 | a Brundin, Lena4 aut |
710 | 2 | a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Journal of Neuroinflammationd : Springer Science and Business Media LLCg 12:1q 12:1x 1742-2094 |
856 | 4 | u https://portal.research.lu.se/files/3095268/8852345.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26338025?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1186/s12974-015-0387-4y FULLTEXT |
856 | 4 | u https://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/s12974-015-0387-4 |
856 | 4 8 | u https://lup.lub.lu.se/record/8043243 |
856 | 4 8 | u https://doi.org/10.1186/s12974-015-0387-4 |
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